The Synthesis Of Cefonicid

Cefonicid is the second generation cephalosporin which has the broad-spectrum antibacterial function by restraining bacilli cellular compound which can give birth to antibacterial active.It can have important effect to gramnegative and gram positive bacteria. It is stable to β-lactamase.We compare the two routes which can synthesize the cefonicid by7-ACA.We find that decorate the3-part of the7-ACA.It is the best route in the factory.So we investigate it very carefully.We compare many condensing agents finding that boron trifluoride diethyl ethera te is the best condensing agent via the3-part condensation.We process the acylation via7-part after that by acid hydrolysis, salting out, salt formation with N,N-dicyclo hexy lethylenediamine,And then the product is exchange by the strong acid cation e xchange resin. Then it reactes with sodium methoxide getting the cefonicid.The total yield is53%. The purity can reach99%.So it matches the request of industrializati on.The final product is verified by NMR.Sodium Bisulfite, formaldehyde, Ammonia Water as the starting materiaLwe get the1-sulfomethyl-tetrazole-5-thiol via condensing, cyclization and so on. The color of product is very well. The total yield is30%.