Studies On Synthesis Of2-arylpyridines And N-allylindoles Catalyzed By Transition-metal | Posted on:2015-04-02 | Degree:Master | Type:Thesis | Country:China | Candidate:Y Shen | Full Text:PDF | GTID:2181330467456956 | Subject:Organic Chemistry | Abstract/Summary: | PDF Full Text Request | The thesis consists of two parts:(1) Copper-catalyzed cross-coupling reaction of pyridine N-oxides with organoboron reagents;(2)Palladium-catalyzed regioselective allylation of indoles with allylicalcohols.The first part: Recent progress in the transition metal-catalyzedcoupling reactions of pyridine N-oxides are described firstly. Then,synthesis of2-arylpyridine derivatives through copper-catalyzed directC-H arylation of pyridine N-oxides with organoboron reagents in one potwas studied. And a possible reaction mechanism was investigated.The second part: Recent progress in the transition metal-catalyzedalkylation of indoles is summarized at first. Then, synthesis ofN-allylindoles through palladium-catalyzed coupling reactions of indoleswith allylic alcohols was invetigated. No acid or base was added and thebyproduct is water. | Keywords/Search Tags: | copper-catalyzed, pyridine N-oxide, arylation, palladium-catalyzed, indole, allylation | PDF Full Text Request | Related items |
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