Studies On The Transition Metal-catalyzed Cyanation And Arylation

C-H bond activation reaction can be used to build C-X（X=C,O,N,S, etc.）, soC-H bond activation reactions are challenging topic in modem synthetic chemistry.C-H bond activation reactions catalyzed by transition metals can be used to shortenthe reaction steps and improve the atom economy. It is a convenient synthetic methodwhich has been widespread investigated by chemists.The cyanation and arylation reactions play an important role in synthetic organicchemistry. The transition metal-catalyzed is an efficient method in formation of C-CNand C-C bonds.This dissertation consists of three parts:The first one focused on the transition metal-catalyzed cyanation. The secondone focused on palladium-catalyzed arylation of heteroarenes.In part one, a brief overview of research progress in recent years on cyanationwas introduced as follows:(1) a iron-catalyzed cyanation reaction oftrimethoxybenzene, indole and aryl pyridine with cuprous cyanide was described.(2)an efficient copper-catalyzed cyanation reaction of phenylboronic acid with DDQ toaccess aryl nitriles has been developed, which represents a facile and practicalmethodology.In part two, palladium-catalyzed arylation reaction were described. Iodobenzenediacetates were used as arylation reagents, a series of functional groups werecompatible under the procedure, and the products were isolated in moderate to goodyields.