Preparation Of Electrospun Nano-hydroxylapatite Nanofibers And Their Research Of Property

Hydroxylapatite [HA,Ca10(PO4)6(OH)2] has the similar chemical structure ofthe mineral component of bone and HA performs a better sorption capability onheavy metal, which can be used as an excellent material for heavy metal ionadsorption. In this paper, hydroxylapatite/polyvinyl alcohol (HA/PVA) hybridnanofibers were prepared by eletrospinning technique with hydroxylapatite asmatrix material, and meso-HA nanofibers with well adsorption ability wereobtained via calcination. After dopanting Cu(CH3COO)2, HA/Cu2O compositenanofibers with antibacterial activity were prepared by reduction in solution.Meso-HA nanofibers with most pores sized at about27nm in diameter havebeen successfully prepared via calcination process from continuous and evenPVA/HA hybrid electrospun nanofibres with average diameters at about500nm.On the basis of experimental data, meso-HA nanofibers performs a bettersorption capability than HA/PVA hybrid nanofibers under the same experimentalcondition. The sorption percentage of Co(II) on meso-HA increases slowly asthe pH at pH <7(region I), increases sharply and reaches a maximum value of92%at pH710(region II), and then maintains a high level at pH>10(regionIII). The sorption of Co(II) on meso-HA nanofibers is strongly affected byforeign ionic strength at pH<9, and independent on foreign ionic strength at pH>9. The kinetic sorption of Co(II) on sorbent agrees well with thepseudo-second-order model. The comparison of isotherm models illustrates thatthe Langmuir model describes the equilibrium data of Co(II) ions sorption betterthan the Freundlich model. The thermodynamic parameters imply that thesorption process is spontaneous and endothermic.PVA/HA/Cu(CH3COO)2composite eletrospun nanofibers were soaked inhydrazine monohydrate solution to obtain HA/Cu2O composite nanofibers. Theeffects of the content of spinning solution, and electrospinning electrical fieldstrength, tip-to-collector distance (TCD) on the morphology and structure of thehybrid fibers were investigated. On the basis of results, the optimal parameterswere determined as following. Cu2O content is40%by weight，electrospinningelectrical field strength at20kV, tip-to-collector distance (TCD) at15cm. TheHA/Cu2O fibrous films exhibit well antimicrobial activity against S. aureus，and the antimicrobial effect is increasing with the increase in the content of Cu2Obelow40%.