Ruthenium (ii) Miscellaneous (aryl) Ring Aldehyde (ketone) Reduction Thiosemicarbazide Synthesis, Characterization And Biological Activity Study

Anti-cancer drugs of metal complex is one of the chemotherapy drugs in clinical application at present. Ruthenium complexes attract researchers' attention because of its characteristic, such as low toxicity, easily absorbed and so on. Thiosemicarbazone compounds generally have anti-bacterial, anti-tumor, anti-parasitic and other biological activity. It can be used as ligands by reason of containing electron donor S, N atoms to form complexes with transition metal ions, which can be promote further expansion of biological activity of thiosemicarbazone compounds.In this paper, cis-[RuCl2(DMSO)4](precursors) is synthesized by the RUCl3.3H2O and DMSO(dimethyl sulfoxide). The six new ruthenium complexes trans-[Ru(Ⅱ)Cl2(DMSO)2(Li～L6)] are synthesized by cis-[RuCl2(DMSO)4](precursors) and heterocycle(aromatic) ring aldehyde(ketone) thiosemicarbazone ligands respectively of benzaldehyde thiosemicarbazone L1, nitrobenzaldehyde thiosemicarbazone L2, acetophenone thiosemicarbazone L3, salicylaldehyde thiosemicarbazone L4, pyridine-2-formaldehyde thiosemicarbazone L5 and furan-2-formaldehyde thiosemicarbazone L6.The ligand, precursors, ruthenium complexes were characterized by IR,1HNMR, The results indicated that:Ligands L1～6 and cis-RuCl2(DMSO)4(precursors) occurs substitution reaction, One molecule of the neutral bidentate ligand replaced one molecule coordinated with the sulfur atom and one molecule DMSO coordinated with oxygen atom in the precursors, The nitrogen atom in imine bond (C=N) and sulfur atoms in thione bond (C=S) coordinated with central ion Ru(Ⅱ) formed octahedral complexes of trans-[Ru(Ⅱ)Cl2(DMSO)2(L)]. Antibacterial test of the six ruthenium complexes using Agar diffusion method was indicated: Ruthenium acetophenone thiosemicarbazone did not produce inhibition of the red yeast and Bacillus subtilis, Others have a certain amount of inhibitory activity. Anti-cancer activity of ruthenium complexes of [Ru(Ⅱ)Cl2(DMSO)2(L2～L6)] was texted by MTT. The results show that the ruthenium acetophenone thiosemicarbazone and ruthenium pyridine-2-formaldehyde thiosemicarbazone indicate inhibition after first promotion, ruthenium salicylaldehyde thiosemicarbazone and ruthenium nitrobenzaldehyde thiosemicarbazone show promotion, ruthenium furans-2-formaldehyde thiosemicarbazone show inhibition.