The Synthesis Of NIR BODIPY Dyes And Its Application In Ion Detection And PDT

Fluorescence spectroscopy, fluorescence imaging and fluorescence indicators are nowadays indispensable tools in various fields of modern science, medicine, biotechnology, materials science, analytical and environmental chemistry. The classic indicator is a molecule capable of transforming chemical information, such as the presence or concentration of a specific analyte, into an analytically useful signal. Among the numerous classes of highly fluorescent dyes, the set based on 4, 4-difluoro-4-bora-3a,4a-diaza-s-indacenel,2(better known as BODIPY)shows perhaps the highest potential and popularity.There are many excellent features of BODIPY dyes:the relatively high molar absorption coefficients and fluorescence quantum yields,excitation/emission wavelengths in the visible spectral region (≥500 nm).Moreover, their spectroscopic and photophysical properties can be fine-tuned by attachment of ancillary residues at the appropriate positions.In the second part we synthesized a new probe by fusing phenanthrene to dipyrromethenes analogue.The probe based on the reaction of Cu2+ with H2S, it displays high selectivity and high sensitivity for H2S.What is more,the probe is harmless for cells,and can be used for fluorescence imaging of H2S in living cells.The third part shows a new kind of compounds Ir(ttp)-BODIPY. These compounds are synthesized by Professor KinShing Chan’s group in CUHK. Conjugation of BODIPYs with porphyrins,we have detected the desirable photochemical and photophysical properties of the new compounds and used as a NIR PDT photosensitizer.This part of work are in progress and we aim to shift the absorption and emission maxima to the longer wavelengths.