| Bimetallic nanoparticles not only has all kinds of excellent properties of nanometer materials and combines the properties of the individual constituents, but also shows an enhancement in specific properties because of the synergistic effects and the rich diversity of the compositions. So it can be widely apply in the electrochemical biosensor. The main contents are summarized as follows:(1) In this work, a new method for determination of glutathione (GSH) was carried out by using acetaminophen as a mediator on a NiPd Nanoparticles modified electrode. The as prepared electrode exhibited excellent electrocatalytic activity for determining GSH with a good linear correlation to GSH concentration in a broad range from 0.5 to 3000μM and a low detection limit of 0.5 μM. The proposed sensor exhibited a good stability, interference and reproducibility and successfully employed to detect GSH in the real samples.(2) An electrochemical sensor for selective detection of ascorbic acid (AA) in the presence of dopamine (DA) and uric acid (UA) was fabricated by modifying the glassy carbon electrode (GCE) with carbon-supported NiCoO2 nanoparticles. The results show that the current sensitivity of AA was enhanced to about five times upon modification. The voltammetric response of AA was well resolved from the responses of DA and UA, Our results demonstrate that the NiCoO2/C nanomaterials has excellent AA sensing capability, including a fast response time, high reproducibility and stability, with great promise in the quantification of AA in real samples.(3) A carbon-supported NiFe nanoparticles modified the glassy carbon electrode was prepared for the simultaneous determination of guanine(G), adenine(A), thymine(T) and cytosine(C). The results demonstrated that the electrochemical sensor developed from NiFe nanoparticles had advantage of high sensitive and good selectivity for determining bases. The proposed sensor exhibited a good stability, interference and reproducibility. |
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