Construction And Application Of Cyclodextrin Pseudorotaxane Chiral Nanochannel

Chirality is one of the essential properties of nature. Chiral recognition and chiral separation play an important role in organic chemistry, medicinal chemistry and biochemistry. Inspired by biological ion channels, manual bio-nanochannels have attracted more and more attention from researchers because of the highly selectivity and gating properties for ions and molecule, in which chiral separation based on bio-nanochannle in chiral membrane which has low power consumption and easily continuous operation has become the focus of research. Thus, design a chiral nanochannel with stability and recyclability to achieve an effective separation of chiral drugs is a challenging job. In this paper, we have built chiral nanochan based on cyclodextrin pseudorotaxane structure, which realize of chiral recognition of the particular chiral molecules using chiral recognition performance of cyclodextrin and the weak interaction with the chiral guest molecules.Therefore, design and development chiral bio-nanochannels based on cyclodextrin chiral rotaxane realize the chiral recognition amino acid and naproxen. On the basis, we further explore the transport effect of naproxen. This paper has carried out the research work of the following three aspects:Firstly, a biomimetic chiral nanochannel build was designed and constructed based on cyclodextrin polyrotaxane structure, which could show selective chiral recognition of phenylalanine. The combining cyclodextrin with the specific binding of L-phenylalanine could change the electric charge on the surface of the channel, and further changed the transmission capacity of electrolyte in the nanometer channel, thus it could realize selective response of L-phenylalanine.Secondly, a biomimetic chiral nanochannel build was designed and constructed based on β-CD polyrotaxane structure, which could show selective chiral recognition of naproxen through the combining cyclodextrin with the specific binding S-naproxen. Moreover, the nanochannel had a good pH responsive performance.Thirdly, the chiral biomimetic nanochannel based on β-CD polyrotaxane structure had a and chiral transport and chiral separation of naproxen in PET porous membrane. Meanwhile we had preliminarily discussed the chiral transport conditions.