The Preparative Process Of Liver-Protection Of Ge Wu Granule And Functional Assessment

Liver-protection of Ge Wu granule is a health food which has auxiliary protective effects on chemical liver injury with radix puerariae, fructus schisandrae, salvia miltiorrhiza, radix paeoniae alba, radix glycyrrhizae as raw material, sugar as supplementary material.In this paper, first of all, radix puerariae, fructus schisandrae, salvia miltiorrhiza, radix paeoniae alba and gansu grassland were identified according to "national pharmacopoeia of the People’s Republic of China (first)". The second, extraction technology and the best conditions of extraction technology were determined; Then the granule were screeninged the best extraction technology by animal experiments and verified its efficacy; Finally, the preparation for molding process were studied.Extraction process:radix puerariae, fructus schisandrae, salvia miltiorrhiza, radix paeoniae alba, radix glycyrrhizae decoction were extracted by water while puerarin and total flavonoids were used as signature ingredient. The optimum extraction conditions: material to solvent is 1:10 (g:mL), extracting time is 1.5h, times of extracting is 3; Radix puerariae, fructus schisandrae, salvia miltiorrhiza were extracted by alcohol while puerarin was used as the signature ingredient. At the same time, the extraction conditions were optimized to be:the ethanol with the concentration of 70%, material to solvent is 1:6 (g:mL), extracting time is 1.5 h, times of extracting is 3; Radix paeoniae alba, radix glycyrrhizae were extracted by waterand and use liquiritin as signature ingredient.The optimum extraction conditions:material to solvent is 1:8 (mL), extracting time is 1.5h, times of extracting is 3.Using functional experiment to select process. The best extractions conditions of two different extraction processes were obtained by orthogonal test. Using functional experiment screening process. At the same time discuss the protective effect on chemical liver injury of liver-protection of Ge Wu granule. Results:Liver-protection of Ge Wu granule has auxiliary protection function on chemical liver injury. At the same time, it can reduce liver damage and liver steatosis. And then it was verified protective effects on alcoholic liver injury, and has the potential to prevent fatty liver function.Finally, the formation techniques were studied. Liver-protection of Ge Wu granule is a health food that has auxiliary protective effect on chemical liver injury and based on dry powder which used the radix puerariae, fructus schisandrae, salvia miltiorrhiza, radix paeoniae alba and radix glycyrrhizae extracted by different extraction technology, made of white granulated sugar as materials. Investigation into the granules dissolve and release quickly, active ingredients are absorbed enough, process routing of experiment is stable, simple, suitable for industrial production. As well as studying the wetting agents, total mixing time, critical relative humidity and the drying time.