Preparation And Application Technology Of Shea Butter Nanoemulsions

Nanoemulsions have been gradually applied in medicine, cosmetics and food, and other fields. Currently, high-energy emulsification method has been successfully used in cosmetics nanoemulsion production. Preparation of stable cosmetic nano emulsion system, covering the efficacy of cosmetic ingredients, reducing the size of the droplets and narrow droplet size distribution of nano-emulsion for application and popularization of great significance.In this paper, nanoemulsions were prepared by high pressure homogenization and the shea butter oil was as oil, Tween80 and Span 80 were as emulsifiers. Pseudo-ternary phase diagrams were employed to find the favorable region for preparing the coarse emulsion, which were subsequently used to prepare nanoemulsions. The coarse emulsion region increased With the addition of 0.2% NaCl. The influence of homogenization pressure and homogenization times on the particle size were invested, and the homogeneous pressure of 100MPa and homogenization times of 8 times were Selected for the next experiments. The impact of the emulsifier content, oil conent and NaCl content on nanoemulsions particle size and PDI were optimized using response surface design methods. The effect of different factors on particle size was oil content> NaCl content> emulsifier content; The effect of different factors on PDI was NaCl content> emulsifier content> oil content.Additives have a significant effect on nanoemulsions. The oil types were found having no regular effect on particle size and PDI. Surfactants have significant influence on zeta-potential and paryicle size of nanoemulsions. With the addition of cationic surfactants, the zeta-potential of nanoemulsion system changed from negative to positive, and the particle size of nanoemulsions decreased first and then increased. A negative increase of the zeta-potential was found when the anionic surfactants were added. The increase of the negative potential was due to the adsorbed of anionic surfactants on the surface of the droplets. The zwitterionic surfactants did not have significant effect on the droplet potential, which means that the charge of the droplets in the system did not change significant.the particle size was slightly reduced as the zwitterionic surfactants added. Glycerin and butylene have a greater impact on particle size, with increasing the amount of glycerin or butyleneparticle, the particle size was increased. The effect of temperature on the stability of nanoemulsions encapsulated resveratrol were studied and the stability of nanoemulsions with different contents of NaCl and glycerol were also investigated. The stability of nanoemulsions include the particle size stability, PDI stability and resveratrol stability. As the time increased, the particle size and PDI at low and high temperatures were not as good as at room temperature. While the content of resveratrol at low temperature were as the same as the nanoemulsions at the room temperature. The stability decreased after adding 0.1% NaCl. The effect of glycerol on the stability was not significant while the stability of resveratrol was enhanced.Compared with nanoemulsions, the ordinary emulsions have a good resveratrol permeability in the early penetration time. Some uncoated resveratrol in the ordinary emulsions was easily penetrated because of the ethanol at the first stage. However, the good permeability of nanoemulsions than ordinary emulsions at last stage illustrated the effect of small particle size on the penetration.