Anti-cancer Drugs Containing Rare Earth Platinum Analogues Synthesis And Activity Of Research

In the last thirty years, the studies of the biological activities of complexes have received tremendous attention. Cisplatin and carplatin as anti-tumor drugs have been used in clinical for many years. Gold compounds poccessing anti-tumor activities have also been developed.The Pt complexes take the most highlights in anti-tumor drugs, other metal ions such as gold, silver, mercury and rare earth were also found having promising anti-tumor drug screening.In this paper, we synthesize twenty complexes of mercury and rare earth. The complexes are HgA NH3(A=C3H2O4,C6H604,C7H804), HgC3H2O4 L(L=C3N2H4, C5H5N), RE2A3 6H20(RE=Dy, Sm, Eu, Gd, Nd):A=C3H2O4, C6H6O4, C7H8O4). Fifty of them are reported at first, weconformed their structure and composing by element analysis, IR and thermo-analysis. By the pharmacology experiment we found that most of them were active anti-tumor complexes.These observations suggest that the mercury compounds may be considered as candidate for potential anti-tumor agents.