Organotin Schiff Base Synthesis, And Characterization Of Complexes

In recent years, organotin complexes of Schiff base has been receiving more attention owing to their catalytic, antibacterial and antitumour activity.In this thesis, more than 30 organotin complexes of Schiff base were sythesized by the reactions of Bu₂SnCl₂, Ph₂SnCl₂, Cy₂SnCl₂, Ph₃SnCl, Cl₃SnCH₂CH₂COOCH₃, Cl₃SnCHCH₃CH₂COOCH₃, Cl₃SnCH₂CH₂COOCy , and Cl₃SnCH₂CH₂COOMen with the Schiff bases of N-(substituted salicylidene)- substituted aminobenzene and N-(substituted salicylidene)-α-amino acid and characteriz ed by means of elemental analysis, IR and NMR spectra. Single crystal structure of the typical organotin compound was determined. The antibacterial activities were also screened .The variations on structure and property were also discussed preliminarily. The thesis contains the following works:1. β-alkoxycarbonylethyl(propyl)tin trichlorides, Cl₃SnCH₂CH₂COOCH₃,Cl₃SnCH₂CH(CH₃)COOCH₃, Cl₃SnCH₂CH₂COOCy and Cl₃SnCH₂CH₂COOMen were synthesized by reactions of acrylate with SnCl₂ and HCl and their complexes with Schiff bases derived from substituted salicylaldehyde and substituted amino benzene were prepared and characterized by means of elemental analysis, IR and ¹HNMR spectra. The results showed that these complexes were six-coordinated by intramolecular carbonyl oxygen and phenolic oxygen of the ligand.2. Organotin complexes with the N-(substituted salicylidene)-a-amino acid derived from substituted salicylaldehyde and a-amino acid were synthesized and characterized by means of elemental analysis, IR, NMR spectra. The results indicated that the diorganotin complexes were five-coordinated by the tridentate ligand ONO and triphenyltin complexes were five-coordinated by phenolic oxygen of the ligand. The crystal structure of Ph₂Sn(OCOCH(i-Pr)N=CHC₆H₂Br-5-0-2) was determined by X-ray crystallography. It was resulted that the tin atom in the compound was that of a distorted trigonal bipyramid with two phenyl groups and the imino N atom in equatorial positions and a phenoxide Ol and a...