The Synthesis Of Functional Substituted Alkyl Tin Compounds, Characterization, And Nature Study

Organotin compounds have been receiving increasing attention in recent years, not only because of their intrinsic interest but also owing to their varied applications such as used as catalysts, stabilizers, biocides, anti-fouling agents and wood preservatives. In recent years, the investigations on the structure mode and biological activities, especially anti-tumor activity have become the focus on organotin chemistry. In this dissertation, series of ester substituted organotin compounds, X_nPh_3-nSnCH₂CHR¹CO₂R(n=1, 2, 3; X=Cl, Br, I; R¹=H, CH₃; R=CH₃, C₆H₁₁), and their complexes with dithiocarbamate and sulfocarbimide were synthesized and characterized by elemental analysis, IR and NMR spectra. the crystal structures of 7 organotin complexes and the antibiological activity of some compounds were determined. The dissertation contains the following works.Ⅰ. Series of β-alkoxycarbonylethyldiphenyltin complexes were synthesized by the reaction of β-alkoxycarbonylethyldiphenyliodidetin and sodium dithiocabamate, silver nitrate, sodium anhydroacetate or potassium sulfocarbimide. 4 β-Alkoxy carbonylethylphenyliotin dihalide were synthesized by the reaction of β-alkoxycarbonylethyldiphenyliomonohalidetin Ph₂XSnCH₂CH₂CO₂Me(X=I, NCS) with ICl and Br₂. The IR and NMR spectra of the 10 compounds which mentioned above and the crystal structures of Ph₂Sn(CH₂CH₂CO₂Me)(S₂CN(CH₂)₄O) and Ph₂Sn(CH₂CH₂CO₂Me)(S₂CN(CH₂)₅) were determined. The results indicate that β-alkoxycarbonyl ethylphenyltin dihalides were pentacoordinate organotin compounds including the co-ordination of intramolecular carbonyl to tin and β-alkoxycarbonylethyl diphenyltin complexes Ph₂LSnCH₂CH₂CO₂Me were tetra-coordinated organotin compounds.Ⅱ. Series of β-alkoxycarbonylethylphenyltin complexes PhL₂SnCH₂CH₂CO₂Me and PhX(SnCH₂CH₂CO₂Me)L were synthesized by the reaction of β-alkoxycarbonylethylphenyltin dihalide PhX₂SnCH₂CH₂CO₂Me (X=Cl, Br, I) with sodium dithiocabamate, potassium sulfocarbimide in the mole rato of 1:1and 1:2, respectively. Studying the reaction of P-alkoxycarbonylethylphenyl-(dithiocabamato)tin halide and silver nitrate, sodium anhydroacetate, potassium sulfocarbimide. A series of organotin complexes with some different ligands substituted were synthesized; IR, NMR spectra of the 12 compounds which mentioned above and the crystal structures of PhSn(CH2CH2CO2Me)(S2C-N(C2H5)2)(NSC) and PhBrSn(CH2CH2 CO2Me)(S2CN(CH2)5) were determined. The results show that p-alkoxycarbonylethylphenyltin complexs PhXnSn(CH2-CH2CO2Me)L2-n (n=0, 1) were penta-coordinated organotin complexs with the bidentate coordination of dithiocabamate to tin .III. Series of p-alkoxycarbonylethyltin dichloride complex C^LSn-CH2CH2CO2R and P-alkoxycarbonylethyltin chloride complexes ClL^Sn-CH2CH2CO2R (L= S2CNR1) were synthesized by the reaction of p-alkoxycarbonylethyltin trichloride Cl3SnCH2CH2 CO2CH3, CbSnC^Cf^CC^CeHn , Cl3SnCH2CH(CH3)CO2CH3 with sodium dithiocabamate in the mole rato of 1:1 and 1:2 respectively. IR, NMR spectra of the 12 compounds which mentioned above and crystal structures of Cl2Sn(CH2CH2CO2Me)(S2CN(CH2)4O) and Cl2Sn(CH2CH(CH3)CO2Me)(S2CN(CH2)5) were determined. The results show that P-alkoxycarbonylethyltin dichloride complexes were sexa-coordinate octahedronal compounds with the co-ordination of intramolecular carbonyl and the bidentate co-ordination of dithiocabamate to tin and p-alkoxycarbonylethyltin chloride complexes were hex-coordinate organotin complex with the bidentate co-ordination of the two dithiocabamate to tin .IV. 3 , Y -dialkoxycarbonylpropyltriphenyltin was synthesized by the reaction of dimethyl itaconate and triphenylstannane; Studying the reaction of PhSnCH2CH(CH2CO2CH3)(CO2CH3) with X2 (X=Br^ Cl) in the mole rato of 1:2; A series of complexes were synthesized by the reaction of P , V -di(alkoxycarbonyl)propylphenyltin dichloride with sodium dithiocabamate and potassium sulfocarbimide. IR spectra of the 5 compounds which mentioned above and the crystal structures of PhChSnO^CH (CH2CO2CH3XCO2CH3) were...