Black Fungus Oral Liquid Preparation And Quality Standards

The auricularia auricula (Auricularia auricula (Hook.) Underw.), gathered in Chinese Medical department raw material for medicine standard [1], is the wooden ear department plant auricularia auricula's dry carpophore. The modern pharmacology research indicated it can obviously reduce blood lipid, but the present auricularia auricula preparation research reports are few. The present paper,based on the modern pharmacology findings and the modern technology, extracts the effective component of auricularia auricula - - the polysaccharide to prepare the oral in order to prevent and treat the hyperlipemia. Though it can meet the clinical needs, and may realize to the comprehensive utilization of auricularia auricula resources, enhances the auricularia auricula added-value.Taking the medical department drugs standard traditional Chinese medicine first volume of auricularia auricula raw material for medicine standard as a foundation the topic appraisal the auricularia auricula raw material for medicine quality by determing the moisture content, the total ash and the ultraviolet spectrophotometric method determination polysaccharide content.In the extraction process research, taking the polysaccharide content as the target, useing the single factor experiment and the orthogonal experiment to inspecte the extraction process, the topic selected the best technological conditions: Takes the auricularia auricula raw material for medicine, adds 40 time of quantity water, 90℃warm soaks withdraws 2 times, each time 3 hours. The polysaccharide obtained-rate under the best extraction technological conditions is 9.26%.Inspecting the auricularia auricula polysaccharide isolate process, the topic adopts the clarifying agent, alcohol, macroporous resin to purify the auricularia auricula polysaccharide, and establishes the polysaccharide extraction quality specification. The clarifying agent method best craft is: The ZTC1+1 natural clarifying agent model isⅡ, firstly joining the B component into the solution before the A component, the clarifying agent amount used is 6%(V/V) first, the solution density (contains crude drugs) as 0.0167g/ml, the heat preservation temperature 20℃, the mixing speed is 200 r/min. The best alcohol purity process is to choose 80% alcohol to purify the auricularia auricula polysaccharide. The best decolorizing-process for the auricularia auricula is on the 40℃and in 10 minitues by 1% of the active carbon.In the quality specification research,the topic has established the auricularia auricula polysaccharide content determination method, has explored the auricularia auricula thin layer distinction initially, and has carried on the preliminary stable inspection to the sample stability. The findings indicated that the oral preparation craft of auricularia auricula is science and feasible; the quality is stable, is controllable, preparation nature basic stable.