Part Of The Study Of Pharmacy, Cai Dan Stagnation Particles

Chaidan jieyu Granule is a compound preparation which consists of five Chinese herbs(Radix Bupleuri, Radix et Rhizoma Salviae Miltiorrhiza, Rhizoma Corydalis, Radix Curcumae, Semen Ziziphi Spinosae). It has the functions of dispersing the stagnated iiver-Qi to relieve restless, promote blood circulation for tranquilization, clear away heat-fire, using in treating insomnia, worriment, headache and all kinds of nerval symptom because of depressing liver, Qi ,and blood. Under the guidance of Traditional Chinese medicine theory, applying modern pharmaceutical technology and according to correlative regulations of patent traditional Chinese medicine, we systematically studied the Preparation process, Quality standard and Preliminary Stability .On the basis of the function and treatment as well as the characers of the effective component of the herbs, the preparation process is designed to studying the extraction of volatile oil, alcohol-extract and water-extract, the optimum extract conditions about alchohol-extract and water-extract were selected by using orthogonal design which use quite a few assessing norms to evaluate them comprehensively. At the same time the optimal condensing and moulding conditions were screened.The quality standard was set up, which includes the thin layer chromatography identification of three Chinese herbs in the prescription and the determination of the content of tanshinoneⅡA and salvianolic acid B assayed by HPLC, which accomplished the systematic methodology.Stability research had kept on 12 months, put the samples under the long experiment at room temperature, the results indicate that Chaidan jieyu Granule was stable and the packing was suitable.All of these studies indicade that the preparation procedure is reasonable and practical, the standard is controllable, the quality of the sample is steady on the whole as well.