Rooster Effervescent Granules

The golden rooster effervesces the pellet is (pellet) changes the dosage-form from the classical name side golden rooster powder. The new dosage-form for effervesces the granular formulation, Therefore by this it. The golden rooster powder gathered in the Chinese pharmacopoeia in 1977 version. Uses in the adnexitis, the womb intimitis, the pelvic inflammatory disease is the hot and damp bottom pouring card the treatment. Take this prescription as the foundation, went on the market the dosage-form has the tablet, the granular formulation, the gelatine capsule, This project is from the golden rooster (powder) the pellet change dosage-form, in the original dosage-form has joined the many carbohydrate ingredient, is not suitable patient's and so on concurrent diabetes taking, because this contraceptive has the good market foundation and the big market demand, developed in this foundation has not had the sugar golden rooster to effervesce the pellet.In the side the cherokee rose root fine astringent intestines, shrink the urine to stop the belt firmly, has the strong bacteriostasis function; CAULIS SPATHOLOBI blood tonic, the blood circulation, passes winds; Thousand catties pull out Shu Jin the strong bone, collects the lung to swallow clear; RADIX ZANTHOXYLI is dry or wet, alleviates heat-producing factors the disintoxicating; Both sides needle dispels symptoms such as bloating the pain-relieving, blood circulation removing extravasted blood, relieves sickness passes winds; Andrographis Paniculta, refrigeration disintoxicating, cold hearted, detumescence.The various plays the refrigeration disintoxicating, is good for the spleen eliminates wet, passes winds effect of the blood circulation.This article in the foundation prescription foundation, the increase effervesces the disintegration medicinal preparation, causes it effectiveness to be rapid, has carried on the optimization through the orthogonal experiment design to the prescription group medicine extraction craft, after namely uses the prescription raw material for medicine to infiltrate for 3 hours, adds 8 time of quantities the water to carry on withdraws 2 times, each time 2 hours, the overall balance various factors, screen the best technological conditions combination, and extracts through the principal components hydrochloric acid berberine content rate the determination to the craft has carried on the confirmation. In concentration craft screening, through the comparison vacuum drying temperature to the effective component influence, chose the vacuum low temperature concentration (-0.09Mpa,60-70℃) to be uitable.Compared to has carried on screening in the preparation craft to the effervescing agent amount used, screens the best proportion is the sodium bicarbonate is 11.25%, the citric acid 7.5%, uses 5% polyethylene glycol to wrap the sodium bicarbonate to effervesce the pellet production craft as the golden rooster.Simultaneously adopts the polyethylene glycol to wrap the craft, the sodium bicarbonate fusing package, solved the acid and alkali to make the pellet which the grain caused to direct separately the wet question.Determined the pellet critical relative humidity to be smaller than 55%. Has established this preparation quality specification through the highly effective liquid phase chromatography.The hydrochloric acid berberine has the biggest absorption in ultraviolet 265nm, therefore the highly effective liquid chromatography chooses the 265nm wave length to take the hydrochloric acid berberine content determination the biggest absorption wave length, with the octadecyl silicon hydride linkage silica gel is the auxiliaries; (Adjusts pH by second grade nitrile-0.05mol/L potassium dihydrogen phosphate buffer solution with phosphoric acid to 3.0) (30:70) is the flowing; After the experiment, under this system condition, the hydrochloric acid berberine peak shape is good, the degree of dissociation is good, the separation factor respectively is: 2.778, the number of theoretical plates achieves 10414 by the hydrochloric acid berberine peak idea. This article has carried on in vitro drug efficacy resist bacteria experiment and the anti-inflammation pharmacology research separately to the prescription drug, in vitro drug efficacy resist bacteria experiment has determined in vitro resist bacteria lowest bacteriostasis density (M IC), the anti-inflammation pharmacology research trial indicated this place side has the obvious anti-inflammation analgesia function, also has certain quantity effect relations.