Curcuma Residual Oil Ointment Preparation And Quality Standards

Purpose: In this paper, basic theories of Chinese medicine as a guide, combined with advanced modern science and technology to conduct traditional Chinese medicine for psoriasis drug - Curcuma residual oil ointment comprehensive study of a standardizedMaterial and method: The uniform design, orthogonal design, single-factor parallel experiment to determine Curcuma residual oil ointment preparation process; the use of HPLC, right Zedoary oil residual active ingredient in the ointment for qualitative and quantitative aspects and in vitro permeability examined.Results:1.With the uniform design, orthogonal design, single-factor experimental method to determine the parallel Curcuma residual oil ointment preparation process as: stearic acid, vaseline, glycerin monostearate, liquid paraffin, triethanolamine, heated to 85℃, stir well, as the oil phase, standby: Weigh sodium lauryl sulfate, glycerin, ethyl p-hydroxybenzoate, laurel diazepam ketone, heating 85℃dissolved in the water phase slowly adding the oil phase, in order to 200r·min^-1 constant stirring to 50℃, adding Zedoary residual oil, and stir to room temperature, the system may Ezhu residual ointment appearance of the best quality.2. TLC method using residual ointment in Curcuma curcumol, curdione, Germacrone for identification, spots were clear separation, Rf values, methods of repeatability and specificity are good.3. HPLC Curcuma residual ointment moving indicator element determination, good linearity, precision, stability, reproducibility and recoveries were up to standard.4. Using isolated rat skin ointment for residual right Curcuma permeability test, Ezhu residual ointment parameters of main components: 10h cumulative infiltration volume curdione Q10 = 133.1μg, curcumol Q10 = 622.9μg, Germacrone Q10 = 1755.3μg; steady-state infiltration rate curdione Js =13.88μg·h^-1·cm^-2, curcumol Js =63.86μg·h^-1·cm^-2, Germacrone Js=195.24μg·h^-1·cm^-2 , showed that Zedoary oil residual ointment three kinds of active ingredients in vitro permeability, high transmittance, infiltration, high-speed, 2% Azone on three kinds of active ingredients to promote infiltration of both the role of different ointments containing doses are significant differences in their permeability.Conclusion:Through a comprehensive standardized Curcuma residual oil ointment study to determine the best formulation of the drug preparation process, established Ezhu residual oil ointment quality standard system, further improved the Curcuma residual oil ointment in vitro permeability studies. Developed a stronger efficacy, active ingredients and mechanism of a clear, quality control, product with high technological content Ointment, has broad application prospects, and Chinese medicine as further research and development to provide reference.