Amino Acid Chelated Iron Absorption In Animals Turn The Law And Applied Research

The study consisted of 2 trials was aimed to evaluate the absorption andtransportation characteristics of ferrous lysine chelate (Fe-Lys) and ferrous glycine(Fe-Gly), and their application.Rat in normal physiological status was chosen as experimental animal mode intrial 1 to evaluate the absorption and transportation characteristics of iron in theform of Fe-Lys and Fe-Gly. Ninety 40-d-old pure Wistar male mice in normal physiological status were used to study the changes of specific ⁵⁹Fe radioactivity and the gross iron content in blood, red cell, serum globin and duodenum at different time (2, 24, 96, 168, 240h) after lavage, and in tissues and organs (liver, spleen, muscle, thighbone) at all times, and major haematology parameters (haemoglobin, serum ferrous, total ferrous -binding capacity) on the 10th day after lavage.In trial 2, Pigs were used to study the application effects of Fe-Lys and Fe-Gly. Seventeen pure Duroc sows were divided into 3 treatments according to the type of ferrous source, which were FeSO₄, Fe-Lys and Fe-Gly (120 mg/kg in sow rations and 150 mg/kg in piglet rations). The application effects of Fe-Lys and Fe-Gly were evaluated by determining iron content in milk in different times (1, 5, 9, 13, 17, 21d) after farrowing, key haematology parameters at different ages (1, 7, 14, 21, 35d) and ferrous content changes in tissues and organs (liver, spleen, muscle, thighbone). Growth rates of pigs were recorded with or without combination of ferriporphyrin via intramuscular injection in order to provide theoretical evidences for scientific, economical use of ferrous amino acid chelate (FAAC),Iron from Fe-Lys and Fe-Gly in purified diet could be absorbed, transported,and utilized easily The Specific ⁵⁹Fe radioactivity and the gross ferrous content infferent hssues and organs supported the conclusfon. Iron from M inconventiOnal diet could be absorbed, tr8nspohed, and utithed bett6r than that homFe-CL with better effect from Fe -LyS than from Fe-GlyFe-Lys and Fe-Gly could increase hon content in sow Inilk to some extentsin comParison with FeSO4. Especially Fe-Lys significantly enhanced iron contentin Inilk. However, there was no obvious law existed in the effectS of Fc-LyS andFe-Gly on ferrous retention in 0d and 2ld-oki pislets. CotnPared with FeSO4,Fe-Lys and Fe-Oly could increase haemogfobin, serum iron in pghtS of differentage. EsPechlly Fe-LyS wiificantly increased haemogfobin content in milk andnotably decreased serum total iron -binding capacity in 14d to35d-old pghtS, wunehad no effects on serum total iro n-binding caPacity in 0d to l4d-old pislets. Fe -Lysand Fc-Gly were excellent ferrous additive and they can replace feniPorphyrin viaIntfamuscular injection. They would promote growth rate greatly if used togetherwith fetriPorphyrin via intramuscular injection. Taken the data supplcmented withFcSO4 +Fe-R during the 0d to 21d Period, 0d tO 35d Period, and 21d to 35d PeriOdl00%, daily wcisht gain of pinlets supplcmented with Fe-LyS + Fe-R wcrc132.62%, 126.72% and 119.94% respectively and those supplemented wihFe-Gly+Fe-R were 113.62%, l16.69% and 1l9.94% resPedely The FAA andferriPorphyrin via intramuscular injection both promoted growth rate of pteletSwificantly As far as ferrous additive was concerned, Fe-Lys group had the besteffeCt. Furthermorc, there existed posithe interaction betwOen FAA (Fc-LyS andFe-Oly and feniPorphyrin via intramuscular injection on cnhanccment of dailybody gain. As far as fermus supplement method was concemcd, Fe-Lys combin6dwAn fenipOrphyrin via intramuscular injeCtion was thc. Deal method to providePguts with iron.