Clinical Analysis Of Effects Of Anticoagulant Treatment On Early-onset Severe Preeclampsia

[Objective]To study the effectiveness and safety of low molecular weight heparin and compound danshen used in women with severe preeclampsia early onset severe preeclampsia[Methods]Retrospective analysis of 95 cases of early onset Severe Preeelampsia via anticoagulant treatment in our department from Oct.2008 to Feb.2010 to be made.It is divided into 3 groups based on anticoagulant drugs.Group A:common clinical scheme, group B:common clinical scheme combined with compound danshen, Group C:common clinical scheme combined with low molecular weight heparin group. Three groups of patients compared blood pressure kidney function, blood coagulation index, the erythrocyte deposited, urine and urinary albumin, edema, postpartum hemorrhage, termination and maternal complications before and after treatment.[The results]1. After treatment artery pressure decreased obviously in three group (P< 0.05), B group and C group were significantly lower than A group of diastolic blood pressure.2.24h urine output increased significantly, urinary protein significantly reduced after treatment, B group and C group is significantly more than A group of urine output, urinary protein quantitative is no significant difference.3. The difference of coagulant function indices of the pregnant women was not statistically significant (P> 0.05).4. The difference of function of liver and kidney of the pregnant women was not statistically significant (P> 0.05).5. The main reason of termination of pregnancy n 3 groups is the maternal complication blood pressure control is not ideal, fetal distress. The differences between groups was statistically significant.6. The pregnancy outcome:the way of termination of pregnancy was uterine-incision delivery. The differences of deliver pregnancy week and neonatal weight was statistically significant.7. The maternal complications in three groups:renal failure, abruption, HELLP syndrome.A group of complications have 16 cases; B group of complications have 12cases; C group of complications have 15 cases, the differences between groups was not statistically significant.[Conclusion]Because of the serious impaction on maternal and child prognosis in early onset severe preeclampsia, we should select strictly suitable cases and carry out effective treatment according to patient's condition, monitor the maternal-fetal situation and select suitable methods of termination of pregnancy to reduce maternal and child adverse pregnancy outcomes. Low molecular weight heparin compound danshen have some clinical effects on severe preeclampsia women and not increase the drug adverse reactions they are safe for the mothers and their fetuses.