Retrospective Analyzing The Change Of Incidence Of Neural Tube Defects In Hospital's Newborn And Folic Acid Intervention In Chang Zhi Heping Hospital Of Shanxi Province From 2000 To 2009

Objective:Analyzing the incidence, type, proportion and influence factors on birth defect(BD) in Chang Zhi heping hospital of Shanxi province from 2000 to 2009, and concluding the experience of BD intervention in our hospital, it provides the evidence for implementing BD intervention and establishing prepotency policy.Methods:According to the definition and diagnostic criteria of 23 categories of birth defect in the《China's birth defects Workbook》adopting the ways of retrospective analysis,analyzing birth number in the hospital(including stillbirth,fetal death, and 28 weeks gestation or infant within 7 days of birth), BD data and neural tube defects number.To conduct statistical analysis according to birth defect in the gender of the newborns, the child-bearing age of mother, geographical distribution and the status of taking folic acid, analyzing and the BD rate in Shan Xi and Hu Nan province.Results:From 2000 to 2009, the total monitored babies amount to 16741,BD babies reach to 228,the probability of BD is 136.19 per 10000. NTDs amount to 139, accounting for 60.96% of children with BD, the probability of NTDs is 83.03 per 10000, the rate of BD and NTDs appear a decrease trend in10 years. There is obvious difference (P<0.05) between the rural and the urban, there is also difference with pregnant women's age; the lowest BD rate is 25～29 years and the highest rate is more than 35 years. The difference was significant (P<0.001). It is statistical significant to compare taking FA and FA taking time, it is also statistical significant to compare the BD rate of Shanxi and Hunan Province during 2001-2005. The incidence of baby sex in BD was no significant(P> 0.05). Conclusion:1 The BD rate of Chang Zhi heping hospital in Shanxi provice appears a decrease trend from 2000 to 2009, the rate declined by 45.58%.2. NTDs is the first place in BD in Chang Zhi heping hospital. The BD is related with pregnant women's year, place of residence life, and taking FA. it is irrelevant with the baby sex.3. In Shan Xi and Hu Nan Province, the incidence of BD exists geographical features. BD focuses on NTDs in Shanxi Province, but it is CHD in Hunan Province.