Ⅰ: The Synthesis And Resolution Research On 2, 2'-dihydroxy-1, 1'-binaphthyl And 2, 2'-diamino-1, 1'-binaphthyl And 2-amino-2'-hydroxy-1, 1'-binaphthyl Ⅱ: The Synthesis Research On Coenzyme Q₁₀

This paper contains two parts basically:(l) The synthesis and resolution on 2,2'-dihydroxy-1,1'-binaphthyl, 2,2'-diamino-l, 1 '-binaphthyl and 2,2'-diamino-1,1'-binaphthyl (2) The explore on how to synthesize Coenzyme Q₁₀.In part one, we introduced the significance and application of 2,2'-dihydroxy-l,1 '-binaphthyl,2,2'-diamino-l,r-binaphthyl and2-amino-2'-hydroxy-1,1'-binaphthyl and their racemate first, after the illumination, we maked detailed discussion and analysis about three compouds mentioned above, then we confirmed their own route of synthesis and resolution through comparison of every route's merit and disadvantage. After finishing synthesized them, we resolved them by chemical method, the enantiomeric excess results were good, furthermore, we used High Performance Liquid Chromatography method to enantioseparate them at the same time, the results of enantioseparation were also satisfying. In part two, we summarized the use, applications foreground and preparation methods evolvement about Coenzyme Q₁₀, after considering the synthesis methods circumspectly, we investigated the preparation of Coenzyme Q₁₀ according to Fujita's methods and we achieved. During the course, we did a lot of work in two aspects: how to remove benzenesulfonyl and benzyl groups, then analyzed the ratio of geometrical isomers after oxidation. It has great consult value on synthesis of Coenzyme Q₁₀.