Clinical Research Of Acellular Dermal Matrix Allograft Combined With Coralline Hydroxy-apatite In Repairing Periapical Tissue Defects

Objective:To evaluate the effects of acellular dermal matrix allograft combined with coralline hydroxyapatite in repairing periapical tissue defects.Methods: 76 cases of chronic apical periodontitis were randomly divided into two groups.In the experimental group(38 cases)which tissue defects were packed with acellular dermal matrix allograft and coralline hydroxyapatite.In the control group(38 cases)which tissue defects were void. Clinical examination and X-ray film after 1 week and 6,12-month follow-up visits to evaluate the effects.Results: After 1 months, all patchs survived, moreover, the defect of gingival tissues that caused by repairing fistula had been healed. After 12 months,the rate of efficiency of the experimental group is 94.7% ,and the rate of efficiency of the control group is 78.9%.there is a significant difference between two groups(χ2=4.15,p<0.05). The bone defect area disappeared 6 months after operation, and the transmission of CHA particles decreased, and, withal, there were some fuzzy images of compact density. It suggested that new bone was growing. The density of CHA particle got closed to normal bone tissue after 12 months, and there were transitional changes of density between CHA with normal bone, which suggested it began to combine with the alveolar bone. Conclusion: The application of acellular dermal matrix allograft combined with coralline hydroxyapatite in repairing periapical tissue defects is effective.