Elemene Combined With Interleukin -2 Pleural Perfusion, Clinical Observations, Treatment Of Malignant Pleural Effusion

Malignant pleural effusion is a kind of common tumor complications, part of the cancer patients because of difficulty breathing first found pleural effusion, and long-term not reduce fluid volume will affect survival in patients with quality. The emergence of massive hydrothorax that patients suffered in surgery, radio-therapy difficult to body blow. Especially, the general condition for late-stage patients, systemic venous chemotherapy poor no significant effect. A lot of hydr-othorax expression is difficulty breathing, can lead to cardiac insufficiency, life-threatening. Conventional pumping fluid cause loss of nutrients, especially proteins, hypoalbuminemia produce leakage of liquid water, make bosom increases, disease accentuate further. So the treatment of malignant pleural effusion, and should begin began there are some difficulties. Recently, the treatment of mali-gnant pleural effusion method more, more for local drug, especially intrathoracic perfusion chemotherapy drugs, but chemotherapy drugs, see more side effects of different degree of bone marrow inhibition and gastrointestinal reaction, espec-ially for the aged, body virtual patients do not appropriate. TCM lumen injections malignant pleural effusion also can achieve the purpose of controlling hydrothorax, another can be appropriately joint biological agents common control hydrothorax, can effectively alleviate clinical symptoms, improve patients'physical condition, can avoid the adverse reaction of chemotherapyObjective:to study the sweet ene milk injection joint preserved interleukin-2 pleural reperfusion malignant pleural effusion patients, whether it is worth the curative effect of clinical further popularized.Methods:Using the method, the selection of retrospective studies with the inclusion criteria 57 patients,57 patients were the first treatment of patients with malignant pleural effusion. Divided into lam sweet ene joint interleukin-2,30 cases in treatment group and control group of interleukin-2 27 cases. Collecting clinical symptoms and fill in the clinical questionnaire, record blood-test, electrocardiogram, liver and kidney function, hydrothorax B to exceed, hydrothorax routine, hydrothorax biochemical, thoracic tumor marker water research content. According to the curative evaluation standard for analysis. Data processing by SPSS,11.0 statistical analysis software to calculate.Results:(1) before treatment group and control group therapy, the patient's age, gender, chest water and KPS score after statistics processing, no significant difference (P>0.05).(2) the treatment group and control group, short-term curative effect by statistical processing, efficient (CR+PR) respectively,43.33%,70% and was significant difference (P<0.05) 0.037 value.(3) treatment group and control group, the quality of life by statistical processing, compare clinical benefit ratio (improve + stable) for 90% and 50% respectively, have significant difference (P<0.05) 0.0007 value.(4) Chest ShuiGong cell count improvement, the treatment group and control group efficient 74.07% effectively 80%, two groups of comparisons no statistically significant meaning.(5) hydrothorax CEA, the treatment group and control group, the CEA down significantly after treatment, but the two groups has no obvious difference between effect comparison.(6) adverse reactions, two groups of cases were caused by drugs not seen liver, kidney abnormalities, ecg changes, gastrointestinal reaction and bone marrow inhibition. Only performance is mild chest pain and fever, after symptomatic treatment can be alleviated.Based on the above results, we think, lam sweet ene milk injection joint interleukin-2 pleural reperfusion malignant pleural effusion, to alleviate the clinical symptoms and improve life treatment.is beneficial, short-term curative effect is relatively prominent, should in clinical widely used.