Allogeneic Blood Transfusion And Autologous Transfusion Perioperative T Lymphocyte Subsets, Nk Cells And Its Clinical Significance

[Objective] To evaluate the effect of allogeneic red blood -cell(RBC) transfusion or acute normovolemie hemodilution(ANH) and autotransfusion on the changes of T-lymphocyte subsets and natural killer [Methods] Thirty patients scheduled for elective resection of rectal,colon or stomach carcinoma,were randomly divided to two groups:patients in group 1 received allogenie red blood cell(RBC) ,patients in group 2 received ANH and autotransfusion.Flow cytometry (FCM) were used to determine the percentages of T-lymphocyte subsets and NK in all lymphocytes.[Resultsl No significant difference were observed in the percentages of T lymphocyte subsets and NK on basic or pre-transfusion level between the two groups. On the 1st day after operation,the percentages of CD3+ CD4+ CD4+/CD8+ and NK decreased significantly in both groups(p<0.05 or p<0.01),but those in allogenie red blood cell group decreased much more markedly. On the 5th day after operation, CD3+ CD4+ CD4+/CD8+ and NK recovered -j - to a normal level in ANH group, but in the allogenic RBC group still in a lower level(p<0.01).[Conclusions] Perioperative allogeneic transfusion ihhibites the patients? immune function seriously for a long time after operation. ANH autotransfusion has little affect on immune system. The inhibited immune function due to anesthesia and operative injury in ANH patients will recover sooner than that in allogeneic RBC transfusion group.