| Allergic disease is a kind of disease which can be caused by any allergic mechanism. These days, accompanied with the varied life style of people, the incidence of allergic disease has a rising tendency year by year. Allergic disease has many origins, and the pathophysiological mechanisms are so complicated that some mechanism have not known up to now. Although western medicine has good curative effect, it has many side effects. A kind of medicine which can be used to prevent allergy is in great need. Chinese medicine has the characteristics of safe and effective, furthermore, it can adjust the whole function of body synthetically. This research has arranged all the document, at the same time, based on the characteristics of allergic disease and the clinical experience of Porofessor Fu Yanling. We have studied the theory foundation and pathophysiological mechanisms of allergic disease. As a result, we choose Scutellaria Decoction (Huangqin Tang) to cure the disease. In order to improve the curative effect, we have arranged to take each main effective ingredient to fill a new prescription. Thereby, we hope to find a safe and effective medicine to cure and provent allergic disease.This paper has two parts: theoretical study and experimental research.The former includes there parts: first, we have discussed the new view of modern medicine on allergic disease, prevention and cure approach, and the newest study progress. Then, we have discussed the treatment based on the syndrome differentiation and other treatment of chinese medicine. On this foundation, we have analyzed all the superiority and insufficient of chinese medicine on the treatment of allergic disease. After that, we have analyzed all the literature about Scutellaria Decoction, and discussed the prevention and cure mechanism of Scutellaria Decoction on the treatment of allergic disease.Experimental research has two parts: Chinese Materia Medica preparation research and the pharmacodynamics study of Scutellaria Decoction on allergic disease. The preparation research includes there parts: first, we have standarded the dosage, source of each Chinese Materia Medica, and the method of making herb decoctions. Then, we have measured each main effective ingredient of Scutellaria Decoction by HPLC. The result is that every 100 ml contained BaiCalin 0.789g, Paeoniflorin 0.420g, Glycyrrhizic acid 0.600g . This result is similar to National Medicine Law. After that, we have produced composite formula of ingredient according to the result.The pharmacodynamics study of Scutellaria Decoction on allergic disease: ① The auricular inflammation of the animal caused by DMSO and croton oil, the result indicated that the effective ingredient group Ⅱ can reduce the auricular inflammation markedly. (Compared with the control group, P＜0.05). ② In the animal skin capillary permeability test, its effect of anti-exudation was observed obviously. The result indicated that the effective ingredient group Ⅱ can reduce the exudation markedly. (Compared with the control group, P＜0.05 ). ③ In the the animal skin pruritus test, the results indicated that the effective ingredient group Ⅱ can inhibit the animal skin pruritus induced by hitamine significantly. (Compared with the control group, P＜0.01). ④ In the passive cutaneous anaphylaxis test, the result indicated that the effective ingredient group Ⅱ can inhibited the passive cutaneous anaphylaxis greatly. (Compared with the control group, P＜0.01). ⑤ In the bronchospasm test caused by the mixture of histamine and acetylcholine, the result indicated that each group of HEC had significant antagonistic effect on the cough caused by mixture of histamine and acetylcholine in normal guinea pigs and prolong the latent period of asthma significantly in guinea pigs. (Compared with the control group, P＜0.01). ⑥ In the bronchospasm test caused by egg-albumin induced sensitization,the result indicated that each group of HEC had significant antagonistic effect ,and prolong the latent period of asthma significantly in... |
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