| OBJECTIVE: To observe the levels of TSH- receptor antibody(TRAb),thyroid stimulating immunoglobulin(TSI), tumor necrosis factor-α(TNF-α)and urinary iodine(UI) between Korean and Han nationality Graves disease(GD) and study the risk factors of GD in Yanbian region. METHODS:1.GD patients:130 GD patients came from inpatient and outpatient and another 8 GD patients were discovered in health examination(2 male,6 female,1 Korean,7 Hans,3 with and 5 without family history of GD).All patients hadn't received antithyroid drug theatment, had normal liver and kidney functions including 37 male,101 female,83 Korean,55 Hans,age 40.65±12.9 y(17～73 y),36 cases with and 102 cases without family history. 2. GD control: 158 healthy controls came from 516 cases with regular health examination. The group included 82 male,76 female, age 40.71±6.49 y(16～60 y),65 Korean,95 Hans,7 cases with and 151 cases without family history. All the subjects were divided into 4 groups(Han GD, Korean GD, Han control and Korean control)and were asked to collect blood and urine samplesin the early morning. We measured the levels of serum TRAb, TSI, free thyroid hormones(FT3,FT4), TSH, TNF-α, and UI, then made statistical comparisons. RESULTS: The results showed that the levels of TRAb, TSI, TNF-α,and UI in GD were significantly higher than those in the control ( TRAb: 1.53 ± 0.26 vs 0.95 ± 0.10, TSI:1.66±0.48 vs 0.79±0.10, TNF-α: 2.08±0.57 vs 1.83±0.53μg/L,UI:335.92±181.06 Vs 245.75±76.80μg/L respectively, P< 0.01). Han control subgroup had higher levels of TRAb, TSI compared with Korean control subgroup ( TRAb:0.98±0.08 vs 0.81±0.11, TSI:0.81±0.11 vs 0.75±0.08 respectively, P< 0.01).The levels of UI had significant difference between Han GD and Han control(355.10±181.09 vs 180.58±79.51μg/L, P< 0.01). CONCLUSIONS: Family history,sex,TRAb,TSI,TNF-α were independent risk factors of GD. The speed and dose of iodine additives may contribute much more to GD patients in Yanbian Han. |
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