| Object To explore the effects of eliminating the stagnant and catharsis on cerebral tissue MDA and SOD levels and on cerebral water content after experimental traumatic brain injury in rats.Method Animals were separated into three groups: sham-operated; control; and eliminating the stagnant and catharsis treatment. On the basis of Feeney's TBI model by free dropping , we measured the levels of MDA and SOD and water content in different time after trauma and treatment.Result1. After TBL the levels of cerebral water content raised gradually in different time and peaked at 24 hour in parietal cerebral cortex in control group than in sham-operated group. (mean眘tandard deviation, 77.53?.20%, 77.96?.21%, 78.91?.13%, 80.42?.24%, 81.27?.30%, P<0.001) Compared control group, the water content declined markedly at 12 hour and at 24 hour in treatment group. P<0.01.2. After TBI, the levels of SOD decreased markedly in different time and peaked at 12 hour in parietal cerebral cortex in control group than in sham-operated group.(mean眘tandard deviation, 93.04?.44, 84.90?.21, 74.75?.43, 59.55?.21, 75.55?.62, PO.001) Compared control group, the levels of SOD raised at 6 hour , 12 hour and 24 hour in treatment group( P<0.05).3. After TBI, the levels of MDA raised markedly in different time and peaked at 12 hour in parietal cerebral cortex in control group than in sham-operated group.(mean眘tandard deviation, 1.86?.22, 2.04?.43, 3.07?.31, 3.47?.15, 3.00?.27, P<0.05) Compared control group, the levels of MDA declined at 6 hour and 12 hour in treatment group(p<0.01)Conclusion:1. After TBI, in wounded region tissue, the levels of cerebral water content raised and the levels of MDA raised either, while the levels of SOD declined.2. The Eliminating the stagnant and catharsis was found to be neuroprotective after TBI. Thus the eliminating the stagnant and catharsis may be a valuable therapeuticinagent in the treatment of TBI. |
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