Yang Drink Experimental Pulmonary Heart Disease And Right Heart Failure, Hemodynamic And Hormonal Changes

Objects: To explore whether the etiology and pathology of wafer-retention caused by yang-deficiency of both Spleen and kidney and the resultant water retention attacking the heart and the lung was related to that of blood rheology retention of water and sodium of the chronic cor pulmonale accompanied by right heart failure.To find out when to use the method of warming yang to resolve retention was the fast time which was able to prevent from occuring the chrome cor pulmonale accompanied by right heart failure,promoting the effect of Chinese drugs in treating this disease.Methods: 48 rabbits were divided into different models:l normal group 2, model group;3,WENYANGHUAYIN formula prevention group of hight dosage 4,WENYANGHUAYIN formula prevention group of low dosage;5,WENYANGHUAYIN foumula treatment group;6,western drug treatment group.Expect the normal group , other 40 rabbits were injected using Fecla water solution from its vein of ears for 21 days.Tube feeding ZHENWU decoction of Chinese herb and Cilazapril of western drug once daily respectly , after 21 days ,blood of rabbits were tested the level of hemodynamics,PRA,AngII, ALD,ANPResults The level of hemodynamics,PRA,AnI,were significantly increasing in model group.Compare with the model group:after prenventing and treating by WENYANGHUAYIN formula,the level of hemodynamics,PRA,ALD,ANP were declined(p<0.05 or p<0.01),but Angll wasn't changed(p>0.05) Compare with western drug group :Chinese drug group reduce the level of hemodynamics superior to western drug group (p<0.05),but western drug group reduce the index of PRA,ALD superior to WENYANGHUAYIN formula prevention group (p<0.05 or p<0.01).WENYANGHUAYIN formula prevention group Compare with WENYANGHUAYIN formula treatment group:prevention group reduced the level of hemodynamics superior to treatment group (p<0.05 or p<0.01).Conclusions: WENYANGHUAYIN decoction can promote index of hemodynamics JPRA,AngII,ALD,ANP, which indicated the etiology and pathology of water retention caused by yang-deficiency of Spleen and Kidney and the resultant water retention attacking the heart and the lung was related to that of blood rheology ,retention of water and sodium of the chronic cor pulmonale accompanied by right heart failure. The effect of WENYANGHUAYIN prevention group was superior to WENYANGHUAYIN treatment group,so preventing by Chinese drugs to prevent was better than treating.