| Objective to investigate the change of collagenâ… and collagen â…¢ in varicose veins, and by this to learn the significance of collagen metabolism during vascular remodeling in varicose veins.Methods Collagen fibres, typeâ… collagen, type â…¢ collagen in 13 normal saphenous veins and 40 varicose veins were studied qualitatively by the methods of H. E, Picrosirius-polarization method. The image analysis system was applied to quantify volume density of typeâ… collagen, type â…¢ collagen.Results The network of collagen is disorganized in varicose vein wall, the change of collagen is different in hypertrophic portions and atrophic portions. The content of collagen was significantly increased in hypertrophic portions intima and identical in atrophic portions intima compared with NSV. The content of collagen had no significant difference in media of three groups. Conclusions The organization of collagen was greatly disturbed in VVs; the change of collagen suggest that hypertrophic portions and atrophic portions represent different step of vascular remodeling. |
