Renal Failure Celebrex Tablets Pharmaceutical And Pharmacodynamic Study

Chronic real failure, the kidney function gradually losing, which can't eject the discards and the poisonous things in the body to the outside, then cause the pathological changes of different degree in every organ of the body. Chronic real failure has great damages:it is bad to every system of the body,the causing and dying rate is very high, the clinic diagnosis is diffcult, the curing cost is high ,and the curing period is long.Though there are not any decent drugs which can reverse the illness changes up to now,we can use reasonable treatments and good medical protecting ways to prevent its' deterioration,which also can put off the time for kidney transplant.In the Traditional Chinese Medicine point of view,Chronic real failure belongs to the Chinese medicine kidney deficiency.Deficiency of the spleen and kindey is the real reason,and the stale-pathogen overtaking SanJiao is the exterior cause, the pathogenesis feature of which has become the common opinions .Now many curing methods can only alleviate a certain degree of the kindey function deficiency,and the expenses are high, such as the kidney transplant and so on.However the Chinese medicine and drugs have a better curative effect on the kindey deficiency,and there are many relative reports about them.This project is based on the above reasons.Main research contents on this lesson including:1.Research into technology of preparation. The technology of preparation is as follows: the optimum processing conditions of Epimedium and Rheum.palmatam.L were studied by orthogonal design with the extraction rate of iccariine and dry cream as detective markers.The result was adding 6 times 70% ethanol to extract for three times, l.Shours each time,which obtains the satisfactory result with repeated examination.The extraction and purifing process of Radix Astragali.and Poria cocos(Schw.)Wolf was studied by orthogonal design with the extraction yield of n-Bunatol lixiviated materials and the weight of dry cream as detective markers;using the yield of n-Bunatol lixiviated materials and dry cream as the detective index while purifying the water-extraction solution with the tape II of NATURAL CLEARING,the best processing condition is adding 8 times amount of water to the drugs,then decoting two times,!.5 hours each time,The optimum purifying condition is condensing the water-extraction solution to the degree, the volume of which is as three times as the material, at 80℃ adding 8%B, after mixing,keeping warm for five minutes,and cooling to 60℃,adding 4%A, after mixing,keeping warm for five minutes,and layingaside 24 hours,filtering,which is superior to the traditional purifying methods.The optimum extraction and purifying conditions obtain the satisfactory result with repeated examination,which can also shorten producing time.2.Research into criteria of quality. All the results of check show that Shenshuaibao Tablets accord with the demands of tablet;after checking by TLC,we determined the way to check Rheum.palmatam.L, Radix Astragali by TLC; Poria cocos(Schw.)Wolf was not recorded because of the inference by blank contarary;Epimedium,without interference's proved to be the characterized ingridents in determining its content.The HPLC shows that the rate of recovery is up to standard and its precisonn,stability and reappearance are good.All the above indicates that the criteria of quality laid down are reasonable and feasible.3.Research on the stability of the Pharmaceuticals. Stability of the Pharmaceuticals was good within the time.4.Research on the Pharmacodynamical experiment.The Pharmacodynamical experiment shows the preparation can promote kidney's ejecting function,prevent the damage to it, can improve the reverse progress of the issue and the function of kidney,also can intensify immune function, prevent its deterioration and put off the progress of Chronic real failure ,which offer a base to clinical use.