| Irritable bowel syndrome is a very common chronic disease of un-o:rganic bowel disorder. The long illness time, abdominal pains, abdominal swell, the habitual change and abnormal character of human excitement are all its main clinic symptoms, besides, the abnormal body function is also its one symptom which is showed as constipation, dysentery and the alternation of these two characters.All of these symptoms show no organic pathology by examine, this disease pathology hasn't been understood entirely so far. However, some professors ascribed this disease to the psychology and the social pressure, the abnormal dynamics of the stomach and abdomen and the excessive sensitive of entrails feeling are IBS's main basis of physiology of the pathogeny, all the population of the patients of IBS occupy half of the ones in the clinic for the digestive system, for 14-22% of the world population. what's more, the increasing trend is accelerating. In the western countries, IBS of diarrhea is more common than IBS of constipation. In our country, the morbidity of different sub-IBS hasn't been recorded in detail. However, the medicine which can improve the syndrome of diarrhea IBS is not available at resent on the market.The Zhushao Yiji Capsules are used for IBS of diarrhea, the symptom which are some uncomfortable feelings of abdomen and can be relieved after defecating, the character of the human excrement will be change and the defecation becomes more frequently. This prescribe comes from clinic application , we choose the best recipe and prove it, combing with the character of the disease which we need to cure , then make it into capsules, the purpose of this subject is making some relative researches before the clinic application.Firstly, The research on the extraction process According to the correlative reference, we determine the dosage's effective element firstly, then choose the suitable extracting technology; extract The Rhizoma Atractylodis, Pericapium citric Reticulatae , Radix Saposhnikoviae, Radix Aucklandiae by alcohol, then extracting the mixture which including herbs which has been extracted and other herbs by water, then the next, purify the final extraction. In order to choose the best corresponding extraction method, all the data which come from the correlative experiment have been analyzed by the software of SPSS.The section of reflux-alcohol extraction: Applying the L9(34) of orthogonal design. The condition of alcohol extraction is determined consulting the pharmacodynamics index (factor: dosage and concentration of alcohol, extraction time, extraction frequency). Optimum processing condition was as following: the condition of reflux-alcohol extraction: 6 times as extraction dosage, 85% as extraction concentration. 3 hours as reflux-extraction time;The section of water extraction: Applying the L9(34) of orthogonal design. Using the content of paeonoside index as the mark, the terms of water extraction (factor: macerated time, water dosage, extraction time and frequency) can be decided. Optimum processing condition was as following: the condition of water extraction: 12 hours as macerated time,8 times as extraction dosage: 2+1 hours extraction time and frequency.The section of refinement by alcohol: Applying the L9(34) of orthogonal design.Using the content of Paeonoside as the mark to optimize the refinement by alcohol. The orthogonal table contains the following factors: the relatively density of extraction liquid, time of alcohol deposition, concentration of alcohol deposition. the optimum condition of refinement was determined: concentrate the extraction liquid's relatively density to 1.08(25℃) ,add ethanol into the extraction until its content proportion is 40%, blend it and then put it in still condition for 24 hours.Research on formation technology: use the content of the immersed substance of ether and Paeonoside as the indexes to make sure that the thick ointment should be evaporated in the temperature of 90℃. for the supplementary materials and its dosage, choose the silica gel as the proper one and... |
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