Lee Shoulder Particles Pharmaceutical Research

The periarthritis of shoulder belongs to blockage syndrome . It is caused by the deficiency of corporeity, impairment of liver and kidney, deficiency of qi and blood, inducing the tendon to innutritious ,the arthrosis to torpid by the pathogenic wind, cold, and dampness attacking the body and retentating in tendons and bones; by the traumatic stagnation, meribians and channels stroked, then the tendon and arthrosis lack nutrition .The clinical character of the disease is shoulder pain and its movement restrained . The treatment with medication is very important therapy. It has been paid more and more attention to find new approach, especially new drugs for healing periarthritis of shoulder.Lijian Granule is originated from a clinical experiential formula. It is composed of nine kinds of herb, such as Radix Astragali praeparata cum melle, Ramulus Cinnamomi, Radix Paeoniae Alba, Radix Angelicae sinensis, Rhizoma Corydalis, Rhizoma chuanxiong, Radix et Rhizoma Asari, Redix et Rhizome Glycyrrhizae praeparata cum melle. Its effect is to replenish qi and blood, regulate yingqi to dredge collaterals and to heal periarthritis of the shoulder.1. SummaryThe cognition of periarthritis of shoulder, the general study situation about the medicinal materials of Li jian Granule.2. The pharmaceutical technology of Lijian Granule.The appropriate conditions of preparations of naphtha was determined by factorial experiment; water solute/ ethanol solute was determined by orthogonal experiment respectively; the means for the package of naphtha byβ-CD was optimized by orthogonal experiment too; the preparation of Li jian Granule is also studied in the thesis.3. The quality standard of Lijian Granule.Some physical characters of Lijian Granule were studied; the TLC authenticate for Radix Astragali praeparata cum melle, Ramulus Cinnamomi, Radix Paeoniae Alba, Radix Angelicae sinensis, Rhizoma Corydalis, Rhizoma chuanxiong, Radix et Rhizoma Asari, Redix et Rhizome Glycyrrhizae praeparata cum melle was fixed. The determination for astragalosideⅣ/Paeoniflorin/dl-tetrahydropal matine was established.4. The stability of Lijian Granule.The stability of Lijian granule in three months has been investigated.