Guben To Phlegm Tongmai Side Drug-containing Serum On Proliferation Of Rat Vsmc And Adhesion Molecule Expression

Atherosclerosis (AS) and coronary heart disease are the common diseases in the cardiovascular system of which causes are still to be identified. The pathogenesis of AS involve abnormal lipid metabolism, injury of vascular endothelium, infiltration of macrophages, proliferation of vascular smooth muscle cells (VSMC), adhesion and aggregation of platelet. The proliferation and apoptosis of VSMC may play important roles. In the normal condition, the proliferation and apoptosis of cells are in dynamic balance, and which maybe protect means to keep the cellular dynamic stability. Recent evidence suggest that the imbalance of proliferation and apoptosis lead to abnormal proliferation of VSMC and the AS conformation. The apoptosis is more common in the restenotic lesion than in the primary AS.The rennin-angiotensin-aldosterone system(RAS) is a main liquid regulation systemin the body, and play an important role in the VSMC proliferation. Researches show that Ang II can promote the synthesis of DNA and proteins in myocardial cells, fibroblasts and VSMC. This effect of Ang II is weak in early phase of cell cycle, but it can significantly promote the synthesis of DNA in later phase and increase the cell numbers.A research found that Ang 11 could induce the neointimal hyperplasia after injury of the carotid artery endothelium in a rat model. Other researches showed that Ang II can promote the VSMC hypertrophy, but can't increase the cell numbers. The recent reseaches focus on the antagonist of RAS including ACEI and Ang II receptor antagonist, which can inhibit the effect of Ang II on VSMC.The current research result confirms, the Chinese medicine is not curing the metabolism synthesizes to advertise for, improving insulin holdout contain affirmative curative effect. Acient medical science ancient works and modern that take a comprehensive view of the experiment cure the house with the clinical research, we think that the metabolism synthesizes to advertise for is on ising evil with phlegm close related, the pathological changes involves many internal organses synthesizes the sex complicacy disease, phlegm evil is pathologic foundation that the pathologic key that the metabolism synthesizes to advertise for the occurrence and develop, metabolize to synthesize to advertise for to belong to the Chinese medicine phlegm certificate.The recent ten years, correlate basic subject of molecular biology and immunology were quickly development, effecting creasinglyto receive to think highly of inflammation in CHD pathogenesy .In process of inflammation, it is the first steps of inflammatory with WBC and BVE the adhere cell BVE cell surface VCAM mediate. In addition,in mediate cell adhesion molecule to cause the accrementition of VSMC and the form Of xanthoma cell, the final,to lead to atherosclerotic plaque. It is important effect for the Cell adhesion molecule Inflammatory reaction in every strage. Therefore, They are certainly opening up the new prospect for the rapeutics and prevention in the study of CAMs for the CHD.In this study, we used method of cell culture of the rat aortic smooth muscle in...