Anti-endotoxin Oral Liquid Pharmaceutical Research

"Antiendotoxin Oral Liguor" is developed on basis of the systematic literature and antiendotoxin and antisepticize experiments out of body according to determination the treatment based on differentiation of symptoms and signs and treating the human body as a whole. It is composed of several Chinese herbs,including Herba Artemisiae Scopariae, Fructus Gardeniae , Radix et Rhizoma Rhei, Fructus Forsythiae and so on, it has the functions to clear away heat and remove toxins ,promote the circulation of blood and remove heat from blood. It is used in clinic to treat endotoxaemia,and has the virtue of quick effect and convenient suage, so patients can easily accept it .According to the rules for national new medicine ,we researched this medcine in preparing technology ,guality standard and tentative stability systemically.All of these provide firm foundation for its clinic study.In the aspect of preparing technology,we studied the herbs for their water absorption rate at first.Weighed every kind of herbs in proportion and soaked them with corresponding volume of water.Every half hours,dissected one sample to check whether it was infiltrated,made sure of the herbs are soaked on the whole after one hour,their water absorption rate is 167.76%;To ensure efficacy of purgation of Radix et Rhizoma Rhei,which is extracted individually and is lixiviated warmly into 20 times amount of boiling water two times ,every time for 20min;then blending the gruffs and other Chinese herbs are extracted by water,then chose the best extracting technology by L₉(3⁴) orthogonal test which regarded water amount, boling time and boling times as the main affecting factors,the best extracting craft is as follow: 10 times amount of water boiling 2 times,every time for 1.5 hours;the extracting liquid is marinated with ethanol,chose the perfect depositing and purifing technology by L₉(3⁴) orthogonal test which regarded the relative density,concentrative degree and the depositing time as the main factors,it's generally examined by extracting rate for dry extraction and the content amount of chlorogenic acid. In the best ethanol depositing craft,the filtrate's relative density should be concentrated to 1.08,the best ethanol proportion is 60% and depositing for 24 hours. In order to ensure the dosage's quality and stability, we added some additional materials.The best materials and its amount were determined as follows: tweens-80 which can increase the solubility of the effective element is 0.5% and sodium benzoate which is the perserative part is 0.2%,we studied it under different pH condition and discovered that pH degree was not needed to be adjusted,kept natural condition can maintain the content of effective element and the taste.In aspects of the quality standard,we used the TLC to identify Herba Artemisiae Scopariae, Fructus Gardeniae , Radix et Rhizoma Rhei,Radix Salviae Miltiorrhizae and Radix Paeoniae Rubra respectively,the separation of the stains was apparent and the negative contrast was not disturbed.All of these proved that the method we used is...