Guanxin Tongmai Capsule Of Inflammatory Cytokines In The Blood Of Patients With Coronary Artery Disease Clinical Research

Objective:To observe the results of indexes for cell-factor and inflummation hurt with different treatments, compare the distinction between Chinese traditional medicine and Western medicine on adjusting the function of heart immunity, antagonizing inflummation reactive scathe, reviving clinical symptom and toxin-side effect, ect, explore unique superiority by the kind of Chinese traditional medicine of ABTBS that illustrate as guanxintongmai capcale(GXTM) .To discuss the medical active mechanism on the facet in antagonizing heart inflammation immunoreation by using the kind of ABTBS, expand the study about affection of Chinese traditional medicine for ruling cardio-vascular disease field inflammation, illuminate the mechanism of antagonizing inflammation by using GXTM to prevention and cure coronary heart disease (CHD), and validate clinical curative effect and clinical applied security, which will establish the base for applying GXTM to more extensive. It may sufficiently dig the developing potential of ABTBS in cardio-immunology field and also may afford the scientific theoretical evidence to develop new medicine mechanism of ABTBS. Method: we adopt Clinic research: all the 60 patients with CHD angina from the first hospital of wuhan were divided into 2 groups: the GXTM group with 30 patients(taking GXTM) and west medicine group with 30 patients(taking west medicinal commixture) at random by adopting the airtight envelope law, which is a single blind random law to observe the influence of patients'cell factors in clinic. Stop the medicine of MTC and the kind of nitric acid ester west medicine for both groups, just keep the routine treatment and physical labor as before. The whole experiment lasts 4 weeks. Indexes will be observed such as security of curative medication, clinical symptomatic, clinical curative effect and ICAM-1, TNF-α before and after treatment. Analyze data by t-test, compare curative effect by Ridit analyse and compare rate by X~2-test. Result: Clinic obverse study result: They have not different remarkably between GXTM group and west medicine group in clinic curative effect, changing of electrocardiogram before and after therapy, p>0.05. In examine about inflammation cell factorial we find though west medicine may reduce the level of inflammation cell factorial of ischemical myocardia, but it has not different remarkably when it compared with before therapy, p>0.05. Inflammation cell factorial of GXTM group drops remarkably which compare with before therapy, p<0.01. They exist different remarkably between GXTM group and west medicine group for the level of inflammation cell factorial of ischemical myocardia, P<0.05.