Acupuncture Baihui "point Of Menopause In Rats Sex Hormones And Effector Organ Effects Of Experimental Research

Background & Objective:The treatment of Western medicine in climacteric syndrome mostly adopt hormone replacement therapy. HRT's curative effect is affirmed in improve vasomotor function ,prevent cardiovascular disease and osteoarthropathia.Howewer,the various contraindication,potential carcinogenic risk,the depressant of immune system,as well as other side effect limits the general application in clinical. The curative effect of acupuncture therapy in CS is affirmed and there is no any adverse effect and poison by-effect being reported.invariably outcom gained in experimental study. The objective of this experiment is through observing the effect in gonadal hormone and its effector organ of climacteriumal rats.Approachs the mechanism of action of acupuncture and moxibustion therapy in femme'CS .And to establish the underlaying for derecting clinical.Methods:40 female Wistar rats(aged 12 months)were randomly divided into four groups(n=10): clima cteric group(CLI),baihui group,shenshu group and baihui and shenshu group.8 female Wistar rats(aged 4 months) is intact group(INT).Made the clima cteric model rat by cut the ovaries.Radioimmunoassay(RIA) was used to measure the level of the estrogen(E₂),follicle-stimulating hormone(FSH) and luteinizing hormone (LH) in the plasma.The change of the morphology of the rat uterus was observed by HE staining. Measure the organs' index of uterus and vagina.Results:Compared with rats of INT group, the plasma E₂ level of rats of CLI group significantly lowered while plasma FSH and LH level significantly increased. Compared with rats of CLI group, the plasma E₂ level of rats of therapy groups significantly increased while plasma FSH and LH level significantly lowered. Compared with rats of INT group, uterus and vagina of rats of CLI group significantly lessened. Compared with rats of CLI group, uterus and vagina of rats of therapy groups significantly increased. Compared with rats of INT group ,endometria of CLI group significantly thinningzed,and glandular organ of infra-endometria significantly decreased. Compared with rats of CLI group, endometria of therapy groups significantly thicked,and glandular organ of infra-endometria significantly increased .There is no significantly discrepancy between therapy groups.Conclusions:The level of sex hormone in plasma of clima cteric rats could be regulated by electro—acupuncture baihui.It's effector organ changed according to.The mechansm likely is regulating the axis of kidney-tiangui-chongren-utrus.