Triblock Copolymer Of Mpeg-plga-mpeg Nanoparticles And Their In Vitro Biological Studies

In the past few years, it is increasingly popular to develop the biodegradable polymeric nanoparticles into high efficient drug release system. Biodegradable polymeric nanoparticles acting as drug carrier have important potential applications such as site-specific drug delivery and controllable drug delivery. However, these carriers cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To overcome this limitation, more and more researchers introduce hydrophilic polyethylene glyeol(PEG) to modify polymeric nanoparticles for avoiding their uptake by reticulo-endothelial system. Introducing PEG changes polymeric nanoparticles' biocompatibility in vivo, thereby influences drug' s properties such as drug release, in vivo biodistribution, et al.Poly (lactic acid-co-glycolic acid)(PLGA) is the copolymer that is provided with excellent biocompatibility and biodegradation. It is finally metabolized into CO₂ and H₂O in vivo and it's semi-metabolized product is lactic acid that participate in the general glycolysis and does not congregate in the important organs. PLGA has been authorized as the pharmaceutical preparation necessities by USA and applied to drug-controlled or sustained release system and nanoparticle preparation. A series of poly(lacticacid-co-glycolicacid)-poly(ethylene glycol) (PLGA-PEG, PELGA) block copolymers and poly (ethylene glycol)-poly(lacticacid-co-glycolicacid)-poly(ethylene-glycol) (PELGE)...