.183 Cases Of Patients With Parkinson Disease Age Of Onset And Clinical Heterogeneity Retrospective Study

AIM: To study the effect of onset age on clinical characters and prognosis of Parkinson disease.METHODS: 74 early-onset patients with Parkinson disease(≤ 50 years of age) and 109 later-onset patients(>50 years of age) were selected from the Department of Neurology in the Second Affiliated Hospital of the Medicine School of Zhe Jiang University from December 2003 to February 2007. The rate of sex, onset age, onset symptoms, family history, nonmotor symptoms and the duration reaching different Hoehn-Yahr stages between early-onset and later-onset patients were compared. RESULTS: The rate of positive family history in the early-onset patients was significantly higher than that of later-onset cases; the rate of combining nonmotor symptoms with Parkinson disease in the later-onset patients was significantly higher than that of early-onset cases; the time interval reaching Hoehn-Yahr stages I —III in early-onset group was significantly longer as compared with that in later-onset patients (P<0.05) . There was no significant difference in the rate of sex and Hoehn-Yahr stages, as well as onset symptoms between early-onset and later-onset patients.CONCLUTION: The onset age does affect the clinical heterogeneity and prognosis of Parkinson disease. Genetics may play a more important role in the early-onset patients.