Heat Blood Circulation Outside The Governance Of Active Rheumatoid Arthritis Clinical Efficacy And Safety Evaluation

Since the etiology and pathogenesy of Rheumatoid Arthritis (RA) have not yet been clarified, the treatment of RA has been difficult to study for setting up a long-term academic hot problem. Currently, the main Western medicine treatment of RA is primarily by Non-Steroidal A-inflammatory Drugs (NSAIDs) and Disease-Modifying Anti-rheumatoid Drug (DMARDs), NSAIDs quickly ease joint pain and inflammation while DMARDs reduce or delay bone destruction. However, the side effects of these drugs are often so difficult to insist on taking patients.External treatment of Traditional Chinese Medicine (TCM) has good effect and fewer side effects. My branch used plastering therapy with clearing up heat and eliminating damp,activating blood circulation and dissipating blood stases as rules to prescribe Chinese herb medicines containing Tripterginum Wilfordii Hook, and the oral Chinese Medicinal Herb affiliated. Plastering therapy both decreased Tripterygium Wilfordii Hook's poisonous side effect, and made up the oral therapy to speed up the slow insufficiency effect. Therefore giving full play to advantages and characteristics of Chinese medicine, protect the joint function of RA patients, and thoroughly studying the exact effect of plastering therapy of active RA count for much.Evaluate the effect and safety of Qingre Huoxue plastering therapy in treating active RA patients with syndrome of retention of damp-heat and blood stasis by a four-week randomized, controlled, single-blind prospective study. This study used the internationally recognized recommendation of RA disease curative effect standards-American College of Rheumatology 20% improvement criteria (ACR20), combined the Health Assessment Questionnaire and the joint partial symptoms and physical signs, as well as TCM syndrome assessment criterion(Chinese material new drug clinical research guidance) together as the curative effect evaluation criteria. The research conclusions are as follows:1. Both the single oral treatment and combination treatment had good curative effect for the treatment of active RA. The rate of ACR20 standards achieved were 34.3% and 12.5%, and the total effective rate were 75.8% and 55.2% on improving the syndrome of damp-heat and blood stasis respectively.2. Qingre Huoxue plastering therapy carried fast curative effect, the average effective time of joint pain and swelling were one-week, RA activie phase shortened so.3. Qingre Huoxue plastering therapy has a true efficacy. The number of the painfull joint, the swelling joint, the tender joint, the index of the joint pain, joint swelling, joint tenderness, morning stiffness time and hands grip have improved significantly; the Health Assessment Questionnaire has been definitely improved; However, the classification of joint function and ESR, CRP improvements were negligible.4. Qingre Huoxue plastering therapy was satisfied with safety and simple operation, and has good prospects and value.