Disease And Syndrome Of Angina Pectoris With Qi Research

Coronary disease is a disease that pose as the most important threats to human life.In western countries, Coronary disease is the most lethal reasons of death.In developing countries, including China, its disease rate and mortality rate were escalating on yearly basis.The discussion of diagnosis methods and the effective preventing and controlling measures of Coronary diseases, reducing the Coronary diseases incidence rate, mortality rate and crippling rate has become an important topic for the medical workers studies.This present paper in ancient literatures foundation, researched the near 10 years of modern literatures of related Coronary disease anginapectoris research progress, to clarify about Qi-deficiency and blood stasis, Qi-deficiency and blood stasis with the Coronary disease angina pectoris relations, summarize Qi-deficiency and blood stasis signs curing method and curing medicines. And through the epidemiology clinical investigation and study, to clarify about Coronary disease anginapectoris Qi-deficiency, blood stasis, Qi-deficiency and blood stasis signs distributed characteristic, utilizes the Logistic regression analysis, determining Qi deficiency, blood stasis, Qi-deficiency and blood stasis diagnosis basis. Through Coronary disease anginapectoris pattern and experimental indicators relational research, discussing Qi-deficiency, blood stasis, Qi-deficiency and blood stasis's biological basis. Through analyzing to the related Coronary disease anginapectoris treatment in modern literature case of illness, choosing the Coronary disease anginapectoris Qi-deficiency and blood stasis sign diagnosis matching criteria and a clear curative effect cases of illness, systematically summarizing Coronary disease anginapectoris Qi-deficiency and blood stasis signs commonly used medicine, the dosage range, the medicine combining, commonly used formula and so on, discussing the treatment of Qi-deficiency and blood stasis signs and its medication rule.1．Modern literature researchThe Coronary disease anginapectoris cause of disease varies with the debility of old age, overacting of emotions, extreme fatigue, dietary irregularities and so on, its pathogenesis related with Yang-deficient, Qi-deficiency, Yin-deficient, congealing cold, phlegm turbidity, Qi-stagnancy, etc. From with, Qi-deficiency and blood stasis is the Coronary disease anginapectoris basic pathogenesis. Treatment of Coronary disease anginapectoris commonly used of formulas: House of Blood Stasis Expelling Decoction (血府逐瘀汤), Yang Supplementing Five-Returning Decoction (补阳还五汤), Peach Kernel and Carthamus Four-agents Decoction (桃红四物汤), Kidney Qi Pill (肾气丸) , Gallbladder-warming Decoction (温胆汤) , Trichosanthes Chinese Chives and Pinellia Decoction (栝�'�薤白半夏汤), Salvia Beverage (丹参饮), Minor Chest-Bind Decoction (小陷胸汤) etc.2．Epidemiology clinical investigation and studyThrough the clinical epidemiology investigation and study, collects the Coronary disease anginapectoris patients of 297 cases, which diagnosed by Coronary angiography. Qi-deficiency 234 examples, occupy the total case of illness 78．8%; Blood stasis 257 examples, occupy the total case of illness 86．5%; Qi-deficiency and blood stasis 201 examples, occupy the complete case of illness 67．7%. The research indicated that, Qi-deficiency and blood stasis is the Coronary disease anginapectoris most main symptoms essential factor.Respectively from Qi-deficiency, blood stasis, Qi-deficiency and blood stasis as the dependent variable, drafts its symptoms and body symptoms as the independent variable, utilizes the Logistic regression analysis, screens Qi-deficiency, blood stasis, Qi-deficiency and blood stasis diagnosis standards, determining its diagnosis basis.Blood stasis diagnosis standard according to the correlation coefficient size arrangement are in turn: tongue arteries purplish and blue (15．7280) , stasis speckle and spot (14．5488) , curled tongue arteries (14．1818) , stabbing pain (13．7902) , gripping pain (13．7743) , astringent pulse (13．5036) , tongue arteries purplish and red (12．6984) .Qi-deficiency diagnosis standard according to the correlation coefficient size arrangement are in turn: faint low voice (9．6150) , fatigue and lack of strength (8．8945) , spontaneous sweating (8．2317) , activity induced (8．1845) , withered-yellow facial complexion (7．6159) , limp aching lumbus and knees (6．9995) , dull pain (5．6460) , tongue enlargement (5．2584) , shortness of breath (4．4093) .Qi-deficiency and blood stasis diagnosis standard according to the correlation coefficient size arrangement are in turn: faint low voice (4．4851) , curled tongue arteries (3．6887) , tongue arteries purplish and blue (2．4424) , fatigue and lack of strength (2．2061) , tongue arteries purplish and red (1．9718) , chest pain (1．6425) , spontaneous sweating (1．4813) , stasis speckle and spot (1．2129) , shortness of breath (1．1010) , activity induced (1．0591) .3．Qi-deficient and blood stasis biological basic researchThis research through Qi-deficiency, blood stasis, Qi-deficiency and blood stasis separately with D-Dimer, CD62P, Fibrinogen (FIB), Tumor Necrosis Factor (TNF) relational research, discusses coronary disease anginapectoris Qi-deficiency, blood stasis, Qi-deficiency and blood stasis pathological change characteristics. The result showed that, Qi-deficiency compares with the non-Qi-deficiency, two groups of each experimental indicators, Qi-deficiency's group D-Dimer, CD62P, FIB is higher than the non-Qi-deficiency group, also has significant differences (P < 0．05 or P < 0．01) , prompts Qi-deficiency and the above 3 standards are most related. Blood stasis compares with the non-blood stasis, two groups of each experimental indicators, blood stasis's group TNF, CD62P are higher than the non-blood stasis group, also has significant differences (P < 0．05 or P < 0．01) , prompts blood stasis and the above 2 targets is most related. Qi-deficiency and blood stasis compares with the non-Qi-deficiency and blood stasis, two groups of each experimental indicators, Qi-deficiency and blood stasis's group D-Dimer, CD62P, FIB is higher than the non-Qi-deficiency and blood stasis group, also has significant differences (P < 0．05 or P < 0．01) , prompts Qi-deficiency and blood stasis and the above 3 targets is most related. The research indicated that, Qi-deficiency, blood stasis, Qi-deficiency and blood stasis pathological changes has their own respective characteristics.4．Research of Qi-deficiency and blood stasis treatment with its medication rulePrimarily using Tsinghua University CNKI hospital knowledge database, by Coronary disease + Chinese medicine therapy + Qi-deficiency and blood stasis, Anginapectoris + Chinese medicine therapy + Qi-deficiency and blood stasis, Chest impediment + Qi-deficiency and blood stasis as the retrieval word, consulted from April, 1992 to October, 2006, consist of 115 domestic literatures. Utilizes Descriptive Statistic and Cluster Analysis statistical method in statistical processing.①The treatment Qi-deficiency and blood stasis sign most commonly used Chinese medicine includes: Ginseng Radix (人参) , Codonopsitis Radix (党参) , Astragali Radix (黄芪) , Honey-fried Licorice (炙甘草), Salviae Miltiorrhizae (丹参) , Ligustici Rhizoma (川芎) , Paeoniae Radix Rubra (赤芍) , Carthami Flos (红花) , Angelicae Sinensis Radix (当�') , Notoginseng Radix (三七) etc.②Separately counts the treatment of Qi-deficiency and blood stasis sign with commonly used Chinese medicine dosage scope and the average amount used, like Astragali Radix (黄芪) amount used scope 100-15g, averaging 32．57g; Codonopsitis Radix (党参) 45-10g, averaging 19．85g; Salviae Miltiorrhizae (丹参) 100-10g, averaging 23．72g; Paeoniae Radix Rubra (赤芍) 30-9g, averaging 13．95g; Angelicae Sinensis Radix (当�') 25-9g, averaging 13．92g etc.③The treatment of Qi-deficiency and blood stasis sign commonly used formula includes: Pulse-Engendering Powder(生脉散), Coronary noⅡ(冠心Ⅱ号), Tangkuei Blood-Supplementing Decoction (当�'补血汤) , Salvia Beverage (丹参饮) , Trichosanthes Chinese Chives and Pinellia Decoction (栝�'�薤白半夏汤), Bupleurum Liver-Coursing Powder (柴胡疏肝散) etc.④The treatment of Qi-deficiency and blood stasis sign with its commonly used combination of medicines: Codonopsitis Radix (党参) and Atractylodis Ovatae Rhizoma (白术) , Pseudostellariae Radix (太子参) and Alismatis Rhizoma (泽泻) , Typhae Pollen (�'�黄) and Cyperi Rhizoma (香附) , Persicae Semen (桃仁) and Carthami Flos (红花) , Saussureae Radix (木香) and Coptidis Rhizoma (黄连) , Amomi Semen Seu Fructus (砂仁) and Santali Lignum (檀香) , Lycii Fructus (枸杞) and fresh/dried Rehmanniae Radix Exsicatta Seu Recens (生/熟地) . 3 medicines combinations includes: Ginseng Radix (人参) , Ophiopogonis Tuber (脉冬) , Schisandrae Fructus (五味子); Honey-fried Licorice (炙甘草), Salviae Miltiorrhizae (丹参) ,Puerariae Radix (葛根) ; Dalbergiae Lignum (降香) , Ligustici Rhizoma (川芎) , Paeoniae Radix Rubra (赤芍) ; Notoginseng Radix (三七) , Cinnamomi Ramulus (桂枝) , Paeoniae Radix Alba (白芍) ; Bupleuri Radix (柴胡) ,Aurantii Fructus (枳壳) , Platycodonis Radix (桔梗) . 4 medicines combinations includes: Astragali Radix (黄芪) , Angelicae Sinensis Radix (当�') , Hirudo Seu Whitmania(水蛭) ,Lumbricus (地龙) ; Trichosanthis Fructus (瓜�'�) ,Allii Bulbus (薤白) , Corydalis Tuber (延胡索) , Curcumae Tuber (郁金) . More than 4 medicines combination includes: Citri Exocarpium (陈皮) , Poria (茯苓) , Pinelliae Tuber (半夏) , Bambusae Caulis in Taeniam (竹茹) , Aurantii Fructus Immaturus (枳实) , Ziziphi Spinosi Semen (酸枣仁) , Polygalae Radix (远志) .⑤The Coronary disease anginapectoris Qi-deficiency and blood stasis sign in clinical often exists with other signs, therefore in basic of boosting Qi and invigorates blood, many experts according to the condition, physique, four season's changes etc, could vary the medicine combinations along with the signs, such as: rectify Qi medicinal (理气药) , phlegm-transforming medicinal (化痰药) , nerve-calming medicinal (安神药), exterior-resolving medicinal (解表药), dampness-disinhibiting medicinal (利湿药) etc.