Coronary Heart Disease With Unstable Angina Pectoris With Qi And Inflammation-related Research

Coronary heart disease(CHD) is a chronic diseases caused by many risk factors. Although many factors (such as age, smoking, drinking, obesity, hypertension, hyperlipidemia, diabetes and genetic, etc.) has been proven with the occurrence of CHD, but also the occurrence of CHD can not be made for all satisfactory explanation. Therefore, leading to CHD and other biological markers, particularly, inflammatory markers (such as white blood cell count, C-reactive protein, interleukin) and other research has become a research hotspot. CHD are the category of "Chest", "heartache" in Traditional Chinese Medicine(TCM). The treatment according to syndrome differentiation is the core and essence of TCM theory. Different syndromes may exist in different biological basis. TCM have the unique advantages to put to use syndrome and disease to prevent and cure Unstable angina (UA).The study invests the syndromes of 125 patients in UA of CHD, makes statistical analysis of their biological parameter detections,and detects their IL-1, IL-6, TNF-a, cell adhesion molecule-1, serum amyloid A, etc. inflammation-related indexes.Aim to investigate the class distribution of different syndromes,and the relation between syndromes with biological parameter detections and inflammation-related indexes. To find simple and effective indexes to judge UA different syndromes to use for clinical.Result:â‘ 125 patients with UA patients with blood stasis syndrome, phlegm syndrome, and Qi stagnation syndrome, cold coagulation card syndrome, qi deficiency syndrome, yin deficiency syndrome, yang deficiency syndrome; documents 31 cases, accounting for 24.6%, mainly by blood stasis syndrome, accounting for 51.61%, followed by qi deficiency syndrome, accounting for 12.9%; two card combinations of 64 cases, accounting for 51.2%, up to Qi deficiency and blood stasis syndrome, accounting for 48.88%, followed by phlegm and blood stasis syndrome, accounting for 14.06%; three card combination 22 cases of qi deficiency,blood stasis and phlegm syndrome, accounting for 28.57%, followed by blood stasis and Qi stagnation syndrome, accounting for 23.81%; four card combinations and rare combination of five cards, accounting for 4.76% and 2.38%; On the basis of Qi deficiency and blood stasis syndrome,two to five card combination changes at Qi deficiency-yin Deficiency-Qi stagnation axis; 51 patients are Qi deficiency and blood stasis syndrome,which account for the total number of cases of 40.80%; 71 patients are actual situation and evidence folders, which account forthe total number of cases of 56.80%.â‘¡Syndrome associated with the biological parameter detections Sperman analysis and Lgistic stepwise regression analysis showed:blood stasis syndrome relate with CHO, DBIL and MCV; Qi deficiency syndrome relate with RBC, MCH, PLT, DBIL; Qi deficiency and blood stasis syndrome relate with RBC, MCH, PLT, DBIL. Logistic regression analysis showed:Mononuclear cells (M), bilirubin, apolipoprotein B (apoB100), apolipoprotein AI (apoAI), white blood cell count (WBC),etc are the main infiuence factors of blood stasis syndrome of CHD; the main infiuence factors of qi deficiency syndrome were red blood cell count (RBC), mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV), the infiuence factors of Qi deficiency and blood stasis syndrome were bilirubin, red blood cell count (RBC), mean corpuscular hemoglobin (MCH), hematocrit (HCT), monocytes (M), mean corpuscular volume (MCV),etc.â‘¢The result of relation between Syndrome with inflammation-related indexes showe:blood stasis syndrome relate with IL-6, TNF-a, intercellular adhesion molecule-1,FIB; Qi deficiency syndrome relate with IL-6, TNF-a, intercellular adhesion molecule-1, hs-CRP,NF-KB; Qi deficiency and blood stasis syndrome relate with IL-6, TNF-a, intercellular adhesion molecule-1.â‘£Inflammation and lipid indexes correlation analysis showed that:SAA positive correlation with TG (r= 0.246, p= 0.004) and IL-1 (r= 0.192, p= 0.025), but negative correlation with apoAI (r=-0.182, p= 0.034); hs-CRP negative correlation with apoAI and B100 (r=-0.179, p= 0.037; r=-0.192, p= 0.025), but positively correlated with ICAM-1 (r = 0.323, p= 0.000); FIB negative correlation with apoAI (r=-0.188, p= 0.029), but positively correlation with IL-1, ICAM-1 (r= 0.301, p= 0.000; r= 0.339, p= 0.000). IL-1 negative correlation with apoAI (r=-0.180, p= 0.036); IL-6 negative correlation with apoAI (r=-0.178, p= 0.039); ICAM-1 negative correlation with HDL (r=-0.217, p= 0.011). Conclusion:â‘ 125 patients with UA patients with blood stasis syndrome, phlegm syndrome, and Qi stagnation syndrome, cold coagulation card syndrome, qi deficiency syndrome, yin deficiency syndrome, yang deficiency syndrome; On the basis of Qi deficiency and blood stasis syndrome,two to five card combination changes at Qi deficiency-yin Deficiency-Qi stagnation axis;Qi deficiency and blood stasis syndrome is the main pathogenesis.â‘¡The blood stasis syndrome of UA relate with CHO, DBIL and MCV; Qi deficiency syndrome relate with RBC, MCH, PLT, DBIL; Qi deficiency and blood stasis syndrome relate with RBC, MCH, PLT, DBIL.CHD blood stasis syndrome,qi deficiency syndrome,Qi deficiency and blood stasis syndrome have its own biology mechanism.â‘¢UA occurrence and development may be associated with inflammation, and the existence of different syndromes abnormal expression of inflammation-related factors. blood stasis syndrome relate with IL-1; Qi deficiency syndrome relate with IL-6, TNF-a, intercellular adhesion molecule-1, NF-KB.â‘£There is correlation between various inflammation-related indicators,also between inflammation-related indicators and blood lipids.CHD occurrence, development may be inflammation-related. Syndrome of blood stasis, qi deficiency, qi deficiency and blood stasis are inflammation-related. The results further support the Atherosclerosis is a chronic inflammatory process. Different syndromes of UA have the inflammatory process and release acute phase proteins.