| Objective:Observe the Gua Luo Xie Bai Ban Xia Tang to coronary heart disease anginapectorisclinical curative effect, And through clinical research, discussing the Gua Luo Xie Bai BanXia Tang to coronary heart disease angina pectoris patient high sensitive C-reactiveprotein,blood fats, and so on intimal media thickness(IMT) of senile carotid influence.Inquiry into its curative effect mechanism also, apply to lay the foundation for the clinicalexpansion.Method:1.Clinical data: 90 the examples extend anginapectoris patients', all come from inHubei subsidiary in medical college xiang fan in Chinese medicine hospital, Conforms to"Practical Internal medicine" thediagnosis standard, the card is theTan Zhuo Bi ZuXing.Press to seek medical advice the sequence is divided into two random, then cure the set,matched control. Before they accept the curing medicine, the objects should have theinvestigate score of Chinese medicine symptom, the medical examine, something elseexamine which related and various safety index check.. Two age, sex, course of illnesses,basic bodies advertise for, angina pectoris strict specific weight graduation are learn bycovariance to handle to have no obvious difference(P＞0.05).Have can compare sex.2.The medical usage: Matched control 42 example, Gives the western medicine for theexpansion coronary artery crown and the improvement cardicmuscle lacks the blood,XiaoXin Tong plan 10mg, Every day 3, and the convention the treatmen to fall the blood pressure,ACEI and the persistent effect calcium oppresses the anti-medicinalpreparation (CCB), whennecessity jointly oppresses the anti-medicinal preparation using the acceptor, mergeing thediabetes and the high lipemia patient simultaneously give the treatment of falling the sugarand falling the fat. Cure the set 48 example, in the comparison group foundation stoppingusing the western medicine and falls the fat medicine of expanding the crown and theimprovement cardic muscle lacks of the blood, only gives medicine of falling presses andfalling the sugar,and takes orally the Gua Luo Xie Bai Ban Xia Tang, 1 medicinalpreparation, the water fries 2 times every day, will divide sooner or later 2 time to take. Two groups stop using the medicine which othertreatment books gets sick in the treatment period,the treatment time take 4 weeks as 1 treatment course, two groups of sickness average perperson treat 2 treatment courses.3.The toxicity and the side-effect: Two sufferer differences carry on theBlood-routine,Urine-routine,Stool-routine,liver function and the kidney function examinationin front and back in the treatment, to make sure the Gua Luo Xie Bai Ban Xia Tang whetherhad any poisonous or side-effects.4.The curative effective observation: Observe two patient treatments in front and backthe symptom, body advertise for, the certificate wait of improvement, high sensitiveC-reactive protein,blood fats, and so on intimal media thickness(IMT) improves thecircumstance, and make to statistics to learn the processing, comparing its curative effect.5.The Stat.method: Calculate the t-text that the data adoption becomes a data, the datause((?)±s) to mean, the count materials are examined with X~2, the grade data with the Riditanalysis.Results:1.The side-effect and the toxicity: Cure the set and matched controls during the periodof clinical studies, all do not appear to respond obviously side-effect and toxicityfunction.The three greatest normal regulationses, the liver and the kidney functions are curedand do not appear the related abnormality change in front and back.2.Clinical curative effect comparison: The symptoms and signs of the patinents of thetwo groups after the treatment are more better than those before the treatment.Comparedbetween the two groups, the treatment group clinical shows results 29 examples, effective 15examples, invalid 4 examples, total effectiveness 91.7%; The matched control clinical showsresults 16 examples, effective 18 examples, invalid 8 examples, total effectiveness 81.0%,after statistics analysis, the total effectiveness has significant difference beween the cure theset and matched control (P＜0.05). After two group of patients treat, blood plasma highsensitive C-reactive protein equally obviously to reduce, have significant difference(P＜0.01);Around two groups treat the group the comparison, before the treatmentthe not obviousdifference, after the treatment the treatment group C-reactive protein level to drop obviouslyhas significant difference compared with the matched control group (P＜0.05). There aresignificant difference beween two groups in the blood fats each target (TG, TC, HDL-C,LDL-C),both have the distinct improvement, the group compares are not obviousdifference(P＞0.05).These indicate the Gua Luo Xie Bai Ban Xia Tang can remarkablyimprovepatient's blood fats level. There are significant difference around two groups in theintimal media thickness level (P＜0.05), and also the treatment group more better than thecomparison group in the intimal media thickness level (P＜0.05), indicated the Gua Luo XieBai Ban Xia Tang to have the certain curativeeffect in improving the coronary atherosclerosisof anginapectoris patient. Above the result indicated the Gua Luo Xie Bai Ban Xia Tang canimprovethe angina pectoris patient clinical symptom, the body drafts, may effectivelyimprove the patient quality of life, reduce being hospitalized rate, reduce the patient pain.3. The Chinese medicine certificate waits the curative effect improvement to compare:Two treatment inside set in front and back the Chinese medicine symptom curative effectcompare, was analyze by Ridit, the P＜0.05, express two medicine to all have the veryobviously improvement to the Chinese medicine symptom.Cure the set obviously high inmatched control.ALL above express the Gua Luo Xie Bai Ban Xia Tang have the obviousimprovement of angina pectoris with xuan bi tong yang and huo tan kai jie.Conclusion:1.The Gua Luo Xie Bai Ban Xia Tang has the accurate curative effect to the coronarydisease angina pectoris patient, may alleviate the coronary disease angina pectoris clinicalsymptom, also has not had the the toxicity and side-effect.2.The Gua Luo Xie Bai Ban Xia Tang may improve the high sensitive C-reactive protein,intimal media thickness(IMT) level of coronary disease angina pectoris patient.3.The Gua Luo Xie Bai Ban Xia Tang may reduce blood fats level of the coronarydisease angina pectoris patient. |
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