Monitoring Of Helicobacter Pylori-related Gastric Precancerous Lesions And Western Intervention

Objective (1) (?)o p(?)o(?)ide the basis for early de(?)eec(?)ion and treatment of preeanceous lesions of gastric carcinom. and reference for early discovery. diagnosis and treatment of gastric cancer. by examining the differences of expression of the CEA and Hp between precancerous lesions of gastric carcinoma patients and gastric cancer patients. (2)To understand synergism of fungistasis and protection of gastric mucosa on precancerous lesions patients, who were treated by the prescription mianly of Chinese traditional baical skullcap root, by observing the therapeutic effect of precancerous lesions of gastric carcinoma patients, who were treated by triple therapy or jointing traditional chinese medicine. Through this study we wanted to explore new ideas.Methods (1)Detected the expression of helicobacter pylori and carcinoembryonic antigen in blood serum by immunochromatographic method and Protein Chip System. Useing immunohistochemistray to detect the expression of helicobacter pylori and carcino-embryonic antigen in gastric mucosa. (2) 83 patients with precancerous lesions were classified triple therapy group and jointing traditional chinese medicine group. The modern medicine group was treated with omeprazole, amoxicillin and colloidal bismuth subcitrate for 7 days. The jointing traditional chinese medicine group on the basis of triple therapy group was treated with the prescription mianly of Chinese tr-aditional baical skullcap root for 21days. After treatment. observed the change on clinical symptoms, Hp and CEA.Results (1) The expression of Hp was deteced on every stages of precancerous lesions and gastric cancer. compared by the detection rate of Hp. precancerous lesions group was higher than gastric cancer group and superficial gastritis group, superficial gastritis group was the lolowest. The differences of the three groups were significant (P＜0.05). The detection rate of Hp in gastric mucosa was obviously higher than in blood serum. (2) Compared by the expression of CEA, the highest group was gastric cancer group. the lowest was superficial gastritis group, both in blood serum and gastric mucosa. The expression of CEA was not detected in nemal stomach mucosa.(3) Through analysis of the positive patients of CEA.found that the positive degree of gastriic cancer group was highest.and the preeancerous lesions group is obviously higher than superficial gastritis group.(4) Jointing traditional chinese medicine group was better than triple therapy group in the improvement of symptoms, the eradication of Hp,and reduction of the expression of Hp andCEA.Conclusion: (1)Hp participate the process of the precancerous lesions and gastric cancer.The expression of Hp could be one of the index ,which monitor the process and curative effect of the precancerous lesions. (2) The expression of CEA could help diagnosis of gastric cancer.It is important to moniitor the precancerous lesions. The expression of CEA in gastric mucosawas better than in blood serum.Detected CEA both in gastric mucosa and blood serum,which could raise the rate of clinical diagnosis.(3)Observering CEA of Hp positive patients was benefit for early discovery, diagnosis and treatment of stomach cancer.(4)jointing traditional chinese medicine could elevate curative effect ofprecancerous lesion.