Toxic Damage Brain Network Comparison Of Clinical Characteristics Before And After Treatment And Related Research

Objective: Studying the onset and evolution of the cerebral ischemia, to observe the before and after change of clinical feature related to toxin possibly(5 nonspecific symptoms:emotionally instability,dull expression,lack of energy,hypersomnia,heavy head) at the acute stage of cerebral ischemia,and simultaneity in search of the relationship between nonspecific symptoms and High-Seneitivity C-reactive protein.Meanwhile, observing the before and after change of the nonspecific symptoms in the group of kudiezi and xuesaitong, probe into the effect of heat-clearing, detoxicating and promoting blood circulation methods in treating stroke in acute stage. Then inversely get the pathogenesis of"toxin damage brain collaterals"in acute stage of stoke.Methods: Patients who got stroke within 72 hours are randomly disparted into groups of kudiezi and xuesaitong,and related information within 72 hours and the 14th day after the onset of stroke is collected,including nonspecific symptoms,Hs-CRP and NIHSS scale. Then statistical analysis is used to view if there is difference between the two groups,and the relationship between nonspecific symptoms and High-Seneitivity C-reactive protein.Results: In the acute stage of stroke, the occurring proportion of nonspecific symptoms is 83.3%, heavy head and lack of energy are more than the rest three symptoms. All the nonspecific symptoms alleviated after treatment in some way. For the five nonspecific symptoms, only the symptoms of lack of energy and heavy head have significant deviation after treatment between the two groups,and P-value is 0.036,0.033(P<0.05), the rest three nonspecific symptoms have no significant deviation after treatment.Within 72 hours after the onset of stroke,the difference of the Hs-CRP between the patients with and without nonspecific symptoms is significant,P=0.017(P<0.05),but in the 14th day there is no significant deviation, P=0.763(P>0.05).Studying the relationship between nonspecific symptoms and Hs-CRP,there is a positive correlation between the number of nonspecific symptoms and the value of Hs-CRP within 72 hours after the onset of stoke,P=0.0359(P<0.05);but there is no positive correlation in the 14th day, P=0.2657(P>0.05).And in the five nonspecific symptoms,only for lake of energy,there is a positive correlation with Hs-CRP,P=0.0428 (P<0.05). About NIHSS,the two groups can both make the score of NIHSS decline in the acute stage of stroke after treatment,and P-value is0.003,0.009(P<0.05),there is significant deviation ,but there is no significant deviation between two groups.Conclusion: From the study,we can see that nonspecific symptoms about toxin in some way occurred or deteriorated by the happening of stroke,and lightened by the ameliorating of stroke.And nonspecific symptoms about toxin occurred with the the High-Seneitivity C-reactive rising up, nonspecific symptoms about toxin ameliorated with High-Seneitivity C-reactive going down. Within 72 hours of the onset of stroke, there are both positive correlations between the number of nonspecific symptoms and the value of Hs-CRP, between the occurance of lack of anergy and the value of Hs-CRP.By observing the two different groups, we concludede that the methods of heat-clearing, detoxicating and activating collaterals is better than that of simple promoting blood circulation and activating collaterals in improving heavy head and lack of energy,but there is no significant deviation about the rest three nonspecific symptoms, then the discussion comes out that there is toxin in pathopoiesis in the acute stage of stroke according to the curative effect of heat-clearing, detoxicating and activating collaterals methods.