Bupleurum Soothing The Liver Decoction Treatment Of Gastroesophageal Reflux Disease Clinical Observation

Objective:This study aimed to evaluate Bupleurum Powder treating Ganwei not type and gastroesophageal reflux disease(GERD)effect.And further study of theory and the two aspects of the role of Bupleurum Powder mechanism.Method:1,Selected 60 cases of patients with GERD,both in August 2006-2007 September Hubei Medical College Hospital in the digestive internal medicine out-patient treatment of cases,all cases are in line with the country in August 1999 of esophageal reflux disease(inflammation) Examining Yantai meeting will be developed diagnostic criteria.TCM and not-for-Gan Wei.Successively by the order were randomly divided into treatment group and control group of 30 cases.In the two groups in age, gender,disease,the severity of symptoms and treatment of Chinese medicine in total score there was no significant difference,comparable (P＞0.05).2,The Observer Group to Bupleurum Powder addition and subtraction,the basic side to Bupleurum 9 g,TGP 15 g,Baizhu 15 g,Fuling 9 g,Chenpi 12 g,Fructus Aurantii(Zhishi)15 g,YU Jincheng 15 g,licorice 6 g.Wu Yu 10g,Huanglian 8 g.cuttlefish bone constipation,with 10 g Zhishi, who used it Tang Fructus Aurantii.The control group to give it bite-10 mg / time,3 times / day treatment.Less severe diseases who served on the drug after the symptoms disappear,and then takingaweek;condition heavier medication for those two weeks,After two weeks of observation effect.Continuous observation of eight weeks.During the treatment of alcohol should quit,quit irritating food,gastroesophageal reflux disease and the effects of drugs.During should closely observe the patient's clinical symptoms,a 15-day out-patient referral,record symptoms,signs of change,before and after treatment,a gastroscope examination,in accordance with domestic esophagitis inflammation grade-level standards of judgement.During treatment were carried out security checks and efficacy of observation.(General physical examination,the three conventional tests,liver and kidney,heart function tests,possible side effects).3,Efficacy standards:cure:clinical symptoms disappeared,esophageal endoscopy review mucosal lesions returned to normal;markedly effective: clinical symptoms improved significantly,esophageal endoscopy review mucosal inflammatory lesions reduce the erosion of two or more effective: to improve clinical symptoms,Endoscopy review mucosal erosion of the esophagus to reduce an inf lammatory lesions;invalid:clinical symptoms and no change endoscopy review.4,Statistical analysis method:data applications SPSS11.5 statistical software for analysis.Rating information using Ridit analysis,counting use of test data,measurement data used t-test.Results:1.Observer Group:clinical cure five cases,15 cases markedly effective, efficient five cases,invalid five cases,the total efficiency of 83.30 percent for the control group:clinical cure three cases,10 cases markedly effective,efficient nine cases,eight cases invalid,the Efficient to 73.30 percent.Difference between the two groups was significant(P＜0.05＞.2.The two groups before and after treatment with Chinese medicine symptom score than before treatment were significantly different(P＜0.01＞;group of Chinese medicine symptom score improved significantly better than the control group(P＜0.05＞.Conclusion:The research suggested that Bupleurum Powder treatment of gastroesophageal reflux disease is a safe and effective prescription and effective than Western medicine.The mechanism may be related to the following aspects:1.Promote the role of gastric emptying 2.Immune regulation 3.Role in gastric acid and 4.Sterilization 5.Neuroendocrine dysfunction on the role of adjustment.Therefore,we have to play advantages of Chinese medicine,better for Integrative Medicine in the treatment of Chinese medicine to promote the development of academic standards,to resolve the majority of patients with pain.