Pediatric Antidiarrheal Particles Pharmaceutical Research

Children diarrhea frequently happened to children. because of its high morbidity,and it does great harm to children's health. If the cure to the desease is delayed or the desease is cured in wrong way,this desease will have great impact on childrens nutrition,growth, development,and even endanger life.the cause of this desease is all kinds of,among these is caused by annular virus infection,it often happened during autumn and winter to the children under two years old. And there is no specificity medicine aimed to enteric virus. The prescription is added or subtracted from GEGENQINLIANTANG, and is also clinical after proven prescription. The article aims to develop some kind of new medicine through the research of its preparation technology and quality standards.During the course of the research on extraction and purification process, based on our analysis of each individual component contained in each herbal medicine in its pharmacological action, pharmadynamics, physical and chemical property, as well as the main action of the whole recipe, its extraction process has been classifed into two parts, i.e. Herba euphorbiae humifusae, Radix scutellariae, Radix puerariae lobatae and cortex magnoliae officinalis are boiled by water; and poria and Fructus hordei germinatus are extracted by water under 80℃. According to L₉(3⁴) orthogonal survey conducted with recovery rate of dry extraction & content of gallic acid as appraising Index, we concluded that the optimum process for extraction by water would be: by heating circumfluence, use 10 times water to extract third times, 2 hours for each time. In the same way, we decid the best process for soaks warm, i.e. use 10 times water, and estract three times, one hour for each time; and the alcohol-sinking process : the alcohol-sinking solution to be made into 50% concentration with a relative density of 1.10g/mL ( Determined among 55±5℃) after 12 hours of alcohol precipitation.In our study on its granules-forming, we decided a final forming process based on our research on concentration of the liquid extract, different kinds of contents, and proportion of forming auxiary materials and dosage of Aspartame, i.e: the percentage of liquid extract 1.30-1.35g/mL (Determined among 55±5℃) , and proportion of powered sugar to dextrine would be 3∶1, and we concluded that when ratio of liquidextract against auxiliary material is kept at 1∶4 and with Aspartame content of 0.5%,it is in a better condition to be formed into a well-mixed gradules with good taste and easy dissolution.In its quality control study, the research conducted for the quality standards of the gradules has included the TLC and content analysis of Herba euphorbiae humifusae. We have a qualitative identification on xiaoerzhixie gradules, it comes out obviously. In accordance with Chinese Parmacopoeia ( 2005 Rev.), a methodological survey has been conducted on the content analysis of Herba euphorbiae humifusae, and it concluded: good linear indications has been shown as a result of the injection for HPLC being controlled within 0.04584μg-0.764μg, linear equation is y=47.079x-0.2256, correlation coefficient r=0.9999; the sample solution remains in a stable condiction within 24hrs, samples recovery rate at 99.15%, RSD% at 2.19%; Concentration designed for a survey ranges from Minimum of -20% to Max. of 50%. its accuracy( from Min to Max.):0.17%,0.41%,0.63%. its veracity( from Min to Max.):0.82%,1.18%, 1.21%. Our experiments has demonstrated that above-mentioned method is easy for manipulation and correct identification, therefore can be adopted for its quality control.