Egfr And Ovarian Cancer Angiogenesis And Chemotherapy Resistance Relationship

Objective To clarify the correlations of epidermal growth factor receptor (EGFR) expression to angiogenesis and chemotherapy resistance of ovarian cancer.Methods Immunohistochemistry PV-6000 technique was used to investigate the expression of EGFR, lung resistance protein(LRP) and microvessel density (MVD) in 102 ovarian specimens. Followed up the chemotherapic effect and survival time after operation .Patients were followed up at least one year, meso-follow-up time was 30 months.Results (1) EGFR, LRP positive rates and MVD in borderline and malignant ovarian specimens were significantly higher than in the normal and benign ones (P<0.01) .(2) EGFR positive expression rates in the tissues of late stage (Ⅲ-Ⅳ), low differentiation and ascites were higher than in early stage (Ⅰ-Ⅱ), high/moderate differentiation and no ascites (P<0.05) .MVD was related to histological grade, residual tumor and ascites. LRP positive expression had no correlation with the clinicopathologic parameters (P >0.05) .(3) Analyzing follow-up data, short-term efficacy of chemotherapy of EGFR and LRP positive expression were 57.14% and 53.70% respectively, which were lower than those in the negative ones (85.00% and 90.91 %)(P=0.031 and P=0.003). The positive rates of EGFR and LRP in patients demonstrating chemotherapy resistance ( 92.86% and 85.71% respectively) were higher than those sensitive to chemotherapy (both 62.50%) (P <0.05) .(4)There was correlation between EGFR and MVD (r=0.548, P<0.01) , EGFR and LRP positive expression (P=0.020) .(5) There were 64 complete data, three-year survival rate was 53.00%. The patients of EGFR, LRP positive expression and chemotherapy resistance had the shorter survival time (P<0.01) , and only LRP positive expression and short-term efficacy of chemotherapy were independently related to survival time (P<0.05) .Conclusions (1)The expression of EGFR in ovarian cancer was related to angiogenesis and chemotherapy resistance.(2)EGFR and LRP expression were related to chemotherapy resistance, detecting the two proteins may be helpful in evaluating chemotherapy efficacy and monitoring chemotherapy resistance for ovarian cancer.(3) LRP expression and short-term efficacy of chemotherapy may predict prognosis independently.