The. Cyathula Alcohol Extract Of Shr Blood Pressure And Et In Experimental Research

Objective:To explore the effects of the ethanol extraction of radix cyathulae on spontaneous hypertensive rats(SHR),the level of endothelin(ET).Method:Forty SHRs were randomly divided into five groups:untreated control group,the high,middle,low dosage group of the ethanol extraction of radix cyathulae,and the enalapril maleate tablets,with eight rats in each group. SBP were measured respectively by tail-cuff technique before therapy and two weeks,four weeks,six weeks,eight weeks after therapy,the level of endothelin(ET) was measured after eight weeks therapy.Results were analyzed by statisties method.There was statistical difference when P＜0.05 and signifieant dieffrence when P＜0.01.Result:Eight weeks treatment later,every ethanol extraction of radix cyathulae groups and the enalapril maleate tablets group,significantly declined the blood pressure of spontaneous hypertensive rats.Compared with that of the bank group,every therapeutic group had significantly differences(P＜0.01).After four weeks,the increased range of enalapril maleate tablets group was obviously preferable to every ethanol extraction of radix cyathulae groups(P＜0.01).After eigth weeks,compared with that of the enalapril maleate tablets group,the hypotensive function of high dosage group had no significant difference(P＞0.05),but that of middle and low dosage groups still had obvious differences(P＜0.01).Meanwhile,every ethanol extraction of radix cyathulae groups decreased their ET content.Conclusion:The hypotensive function of the ethanol extraction of radix cyathulae may be related to the level of ET.