Rhubarb Dispensing Granule Pharmacy Part Of The Study

Dahuang(Radix et Rhizoma Rhei) is a common traditional Chinese Medicine, which has a long history in our country.It is carry in the《Shengnong Bencao Jing》,list as the low grade.It has special functions,such as expelling pathogenic heat to lossen the intestine,cooling blood to remove pathogenic heat,dissipating blood stasis to promote menstruation;in clinic,it is always used in asthenia constipation of heat,dyspeptic diarrhea causing abdominal pain,diarrhea,jaundice with damp-heat pathogen, vomiting with hemopyrexia and vise vasa.The appfication of Dahuang is extensive in the traditional Chinese Medicine clinical.It has the important position and the demand is very big.The traditional soup takes to have great capacity,its quantity is unsteady, and it is inconvenient to decoction,to eat and to take.So made its system as the quantifying stability and centrally,measuring accurately,taking convenient,validate safety have important meaning.The main research in this artide is the pharmaceutics.It includes preparation procedudure,quality standard(including Fingerprint) and stability.Referring to the traditional,we work out the new processable rule.On the basis of function and treatment as well as the properties of the effective component of drugs,decide to use crossing-experiment.The optimum extract conditions were herbs made by processing and extracted with water 3times,nsing 9 volumes of water for the first time,and 8 volumes of water for the last two times.The purifying technology were separated by high speed centrifugal filter(12000r/min,15min),and condense the liquid after purity to the paste with density 1.02～1.10(60℃).And then combined and dried by spray.Follow the condition to spray as this:speed of enter liquid:50～60ml/min;temperature of enter breeze:160～165℃;temperature of out breeze:85～90℃.Added some adjuvant to the dear extract to make granulation,and then made granules.Meanwhile,the quality standard of Dahuang Formula Granule was made,which includes name,ingredients,procedure,description,identification,other requirements, assay,action,indication,usage and dosage,specification,storage and precaution.The stability was fulfilled,which indicates that the preparation technique of was reasonable and practical,the standard was controllable,and the quality of the sample was steady on the whole as well.Furthermore,HPLC fingerprint identification methods have been studied to a certain extent.And the HPLC fingerprint identification methods is a creation in the research.The results of pharmacodynamics and acute toxicity indicate that Dahuang Formula Granule is safe and effective compared with Dahuang Formula Granule slice.It looked from pharmacodynamics and acute toxicity appraisal result that the Dahuang dispensing granule substitution tradition decoctum is feasible.All the above experiments prove that the preparation technique is reasonable and practicable,the standard is controllable,and the finished product is safe and effective as well as stable."Study on the Quality Standard of Rhubarb Dispensing Granule"is the national 863 scientific and technological project.The research on rhubarb estabarb the quality standard of rhubarb preparation products and final products,can get some information from the experimental data.