Serum Adiponectin In Type 2 Diabetic Nephropathy In Different Periods In The Changes

Objective To investigate serum adiponectin changes in different stages of type-2 diabetic nephropaphy through detecting serum adiponectin,albumin excretion rate.Methods Sixty type-2 diabetic nephropathy patients were divided into normal proteinuria group,micro-proteinuria group and macro-proteinuria group according to urine albumin excretion rate in 24 hours.Twenty health subjects were enrolled as controls.The serum adiponectin was detected,blood glucose and lipid were observed.The differences of adiponectin among the groups and its association with the above parameters were analyzed.Results The levels of serum adiponectin was higher in control than in i normal proteinuria group.(P<0.01)。The serum adiponectin in macro-proteinuria group was the highest of the three patients groups.The serum adiponectin concentration was significantly higher in macro-proteinuria group than in micro-proteinuria group(P<0.05)。And the serum adiponectin in micro-proteinuria group was higher than that in normal proteinuria group.(P<0.05).The differences of serum adiponectin level between normal controls and those in normal proteinuria group;between macro-proteinuria group and micro-proteinuria group;and micro-proteinuria group and normal proteinuria group were dramatically significant(F=14.227,q=2.82-3.73, P<0.05).Serum adiponectin level showed a positive correlation with the amount of albuminuria excretion and serum creatinine(r=0.633,0.316;P<0.05),and it revealed a negative correlation with blood glucose and triglyceride(r=-0.306,-0.295;P<0.05).Conclusion The level of serum adiponectin in type-2 diabetic nephropathy patients increases with the increase of proteinuria and serum creatinine,and shows a close association with glycometobolism.